Registration Dossier
Registration Dossier
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EC number: 208-782-7 | CAS number: 541-47-9
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1996-12-10-1996-12-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP declaration, sufficient information available
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3-methylcrotonic acid
- EC Number:
- 208-782-7
- EC Name:
- 3-methylcrotonic acid
- Cas Number:
- 541-47-9
- Molecular formula:
- C5H8O2
- IUPAC Name:
- 3-methylbut-2-enoic acid
- Test material form:
- other: solid melt, dark brown
- Details on test material:
- purity: 91.7 %, Storage: 7+/-2 °C, dark protected, max. water solubility: 58-60 mg/L
Constituent 1
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- During the whole test procedure the animals were not fed. 7 fish were used per concentration and control. Average body weight at the test start: 0.4 g. Average body length at the test start: 2.2 cm
Study design
- Limit test:
- yes
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 67 [mg/L] CaCO3
- Test temperature:
- 21.1-21.5 °C
- pH:
- 5.60-7.58
- Details on test conditions:
- A static test was performed.
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 60 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: -
- Details on results:
- Quality criteria: The study was performed according to OECD-guideline 203 and GLP- guidelines. The quality criteria were fullfilled: O2 saturation: > 60 % , Mortality in the control was 0% .
Applicant's summary and conclusion
- Conclusions:
- On the basis of the observations made in the test the NOEC was determined at the concentration of > 60 [mg/L] (nominal concentration) of the test substance.
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