Registration Dossier
Registration Dossier
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EC number: 642-362-8 | CAS number: 1190630-03-5
Carcinogenicity
Administrative data
Description of key information
Waiver. Study scientifically unjustified
Key value for chemical safety assessment
Justification for classification or non-classification
Based on the weight of evidence, thedata is waived as testing is not a scientifically necessary option for this endpoint.
Additional information
Ziegler Bottoms are characterized as comprising of two primary constituents; icosan-1-ol and docosan-1-ol. Together these constituents represent a structural class of components (alcohols) that constitute approximately 82% of the composition of Ziegler Bottoms. Study data, where available, for each of these primary constituents has been evaluated and considered together. In a conservative approach the most sensitive study result from across the two constituents has been identified and used to address the endpoint in question.
In accordance with Column 2 of REACH Annex X, the carcinogenicity study (required in Section 8.9.1) does not need to be conducted since both supporting substances (docoan-1-ol and icosan-1-ol) are not classified as mutagen Category 3, and there is no evidence from repeated dose toxicity studies that these substances in this category have any potential to cause hyperplasia or pre-neoplastic lesions.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
