Registration Dossier
Registration Dossier
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EC number: 231-441-9 | CAS number: 7550-45-0
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Accidental release of titanium tetrachloride (TiCl4) in the context of major hazards-spill behaviour REACTPOOL
- Author:
- Kapias T, Griffiths RF
- Year:
- 2 005
- Bibliographic source:
- Journal of Hazardous Materials A119: 41-52
- Reference Type:
- publication
- Title:
- Epidemiologic Study of Lung Cancer Mortality in Workers Exposed to Titanium Tetrachloride
- Author:
- Fayerweather WE, Karns ME, Gilby PG, Chen JL
- Year:
- 1 992
- Bibliographic source:
- J. Occup. Med. 34(2): 164-169
- Reference Type:
- publication
- Title:
- Toxicological profile for titanium tetrachloride.
- Author:
- Agency for Toxic Substances and Disease Registry (ATSDR)
- Year:
- 1 997
- Bibliographic source:
- Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.
Materials and methods
- Principles of method if other than guideline:
- Rats were exposed to the test substance via inhalation. The LC50 (4h) was determined.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Titanium tetrachloride
- EC Number:
- 231-441-9
- EC Name:
- Titanium tetrachloride
- Cas Number:
- 7550-45-0
- Molecular formula:
- Cl4Ti
- IUPAC Name:
- titanium tetrachloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- unknown
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- head only
- Vehicle:
- other: unknown
- Details on inhalation exposure:
- unknown
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- unknown
- No. of animals per sex per dose:
- unknown
- Control animals:
- not specified
- Details on study design:
- unknown
- Statistics:
- unknown
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 0.46 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: Death was attributed to pulmonary edema (=> corrosive properties of TiCl4)
- Mortality:
- Death was attributed to pulmonary edema and occurred during exposures and up to one week post
exposure. - Clinical signs:
- other: unknown
- Body weight:
- unknown
- Gross pathology:
- unknown
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
