Potassium Lauroyl Wheat Amino Acids

Boiling point

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From November 09, 2017 to November 27, 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Deviations:

not specified

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

not specified

GLP compliance:

yes

Type of method:

differential scanning calorimetry

Key result

Boiling pt.:

ca. 100.92 - ca. 101.7 °C

Atm. press.:

ca. 101.375 kPa

Decomposition:

no

Table of results (Screening Tests)

	Clear Phase	Yellow Paste Phase	Both Phases Mixed Together
Endotherm onset temp. (°C)	100.95	101.70	100.92
Mass of Sample Used (g)	4.65	5.50	2.69
Start Temperature (°C)	20	20	20
Final Temperature (°C)	500	500	500
Scan Rate (K/min)	10	10	10
On completion of testing	Black residue on the base of pan	Black residue on the base of pan and lid	Black residue on the base of pan and lid

 

Result: 100.92 – 101.7 °C.

Comment

DSC screening runs were run to support boiling point analysis as the sample separates into two layers, an upper light brown opaque layer and a lower clear layer. The DSC analysis would imply that a single solvent is present throughout the sample and consequently the upper layer is due to a suspension / emulsion that separates out from the liquid as opposed to two immiscible solvent layers.

Conclusions:

Under the study conditions, the boiling point temperature of the test substance was determined to range from 100.92 to 101.7 °C.

Executive summary:

A study was conducted to determinet the boiling point of the test substance using the Differential Scanning Calorimetry (DSC) method, according to OECD Guideline 103 and EU Method A2, in compliance with GLP. Under the study conditions, the boiling point temperature of the test substance was determined to range from 100.92 to 101.7 °C (Chilworth, 2017).

Reference 2

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

From November 09, 2017 to November 27, 2017

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Deviations:

not specified

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

not specified

GLP compliance:

yes

Type of method:

method according to Siwoloboff

Key result

Boiling pt.:

ca. 99.4 °C

Atm. press.:

ca. 102.3 kPa

Decomposition:

no

Remarks on result:

other: Corrected due to barometric pressure

Full test results:

Pressure (kPa) : 102.3

Run Number	Mass of sample Used (g)	Boiling Temperature (°C)
1	0.205	99.8
2	0.184	99.9
Mean Boiling Temp (°C)	99.9

 

Result: 99.4°C (Corrected due to barometric pressure)

 

Comments

A sample (~2 mL) of the lower clear layer was removed from the test sample and transferred to a 20 mL vial. Approximately 0.2 g of this material was then transferred to a small boiling tube for testing. During the first run, the sample first started travelling back up the capillary tube at 106.0 °C. However bubbles were still observed leaving the bottom of the capillary tube in bursts. Following the evolution of bubbles, the liquid then immediately travelled back up the tube. The amount the liquid that travelled back up the tube increased as the sample cooled. Bubbles leaving the capillary tube continued until the temperature reached approximately 101 °C. This was considered typical behaviour and two further runs were performed. It was not possible to test the upper layer using the Siwoloboff method as it is not possible to observe the capillary tube through an opaque layer.

Conclusions:

Under the study conditions, the boiling point temperature of the test substance was determined to be 99.4°C.

Executive summary:

A study was conducted to determined the boiling point of the test substance, using the Siwoloboff method, according to OECD Guideline 103 and EU Method A.2, in compliance with GLP. A sample (~2 mL) of the lower clear layer was removed from the test sample and transferred to a 20 mL vial. Approximately 0.2 g of this material was then transferred to a small boiling tube for testing. During the first run, the sample first started travelling back up the capillary tube at 106.0 °C. However bubbles were still observed leaving the bottom of the capillary tube in bursts. Following the evolution of bubbles, the liquid then immediately travelled back up the tube. The amount the liquid that travelled back up the tube increased as the sample cooled. Bubbles leaving the capillary tube continued until the temperature reached approximately 101 °C. This was considered typical behaviour and two further runs were performed. It was not possible to test the upper layer using the Siwoloboff method as it is not possible to observe the capillary tube through an opaque layer. Under the study conditions, the mean boiling point temperature of the test substance (after correction of barometric pressure) was determined to be 99.4°C (Chilworth, 2017).

Description of key information

Boiling point of the test substance was determined using the Siwoloboff and Differential Scanning Calorimetry (DSC) methods according to OECD Guideline 103 and EU Method A.2 (Chilworth, 2017).

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

99.4 °C

Additional information

- Boiling point by Siwoloboff method: 99.4 °C; the test sample separated into two layers, an upper light brown opaque layer and a lower clear layer. It was not possible to test the upper layer using the Siwoloboff method as it was not possible to observe the capillary tube through an opaque layer.

- Boiling point by Differential Scanning Calorimetry (DSC method) : 100.92 - 101.7 °C; The DSC screening runs were run to support boiling point analysis and it implied that a single solvent is present throughout the sample and consequently the upper layer is due to a suspension / emulsion that separates out from the liquid as opposed to two immiscible solvent layers.

Therefore, the boiling point of the test substance can be considered to range from 99.4 to 101.7°C.