Registration Dossier
Registration Dossier
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EC number: 453-060-9 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 96/54/EG, B.1tris (Akute-toxische-Klassen-Methode)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test animals
- Species:
- other: rat, Wistar Hsd Cpb:WU
Administration / exposure
- Vehicle:
- other: Demineralisiertes Wasser "ENGLISH" Demineralized water
Results and discussion
Effect levels
- Sex:
- male/female
- Mortality:
- Male: 200 mg/kg bw; Number of animals: 3; Number of deaths: 0
Male: 500 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 200 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 500 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 3 - Clinical signs:
- other: Signs of toxicity related to dose levels: Bei 200 und 500 mg/kg KGW. wurden keine klinischen Symptome beobachtet. 2000 mg/kg KGW: Beobachtet wurden: abnehmender Bewegungsdrang, gesträubtes Fell. Alle drei weiblichen Tiere der 2000 mg/kg Dosi
- Gross pathology:
- Effects on organs:
Bei der Autopsie der während des Studienverlaufs gestorbenen
Tiere wurden die folgenden Veränderungen festgestellt:
Aufgetriebener Magen und Dünndarm, geröteter Magen und
gerötete Darmschleimhaut, Schwund von
Magenschleimhautfalten.
Bei den nach Ende der Studie getöteten Tieren wurden keine
auffälligen pathologischen Befunde beobachtet.
"ENGLISH"
The following changes were determined during the necropsy of
the animals that died during the course of the study:
Distended stomach and small intestine, reddened stomach and
reddened intestinal mucous membrane, disappearance of folds
in the mucous membrane of the stomach.
No conspicuous pathological findings were observed in the
animals killed at the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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