Registration Dossier
Registration Dossier
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EC number: 410-510-9 | CAS number: 86753-82-4
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.6 (Skin Sensitisation)
- GLP compliance:
- yes
- Type of study:
- not specified
Test material
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: intradermal and topical
- Vehicle:
- corn oil
- Concentration / amount:
- concentration of test material:
Intradermal:0.03%
topical:75%
concentration of test material used for each challenge:
topical:75% and 30%
topical: 30% and 10%
Challengeopen allclose all
- Route:
- other: topical
- Vehicle:
- corn oil
- Concentration / amount:
- concentration of test material:
Intradermal:0.03%
topical:75%
concentration of test material used for each challenge:
topical:75% and 30%
topical: 30% and 10%
- No. of animals per dose:
- 20
- Positive control substance(s):
- no
- Remarks:
- 10 animals - negative control
Results and discussion
Any other information on results incl. tables
Maximum concentration not causing irritating effects in preliminary test:75%
Signs of irritation during induction: none
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- not classified
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