Registration Dossier
Registration Dossier
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EC number: 700-155-0 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In a study according to OECD TG 429 and GLP, the test item peroxidised corn oil dissolved in acetone:olive oil (4+1 v/v) was assessed for its possible contact allergenic potential.
For this purpose a local lymph node assay was performed using test item concentrations of 25, 50 (w/v), and 100%. The highest concentration tested was the highest concentration that could be achieved whilst avoiding systemic toxicity and excessive local skin irritation as confirmed by a pre-experiment.
The animals did not show any signs of systemic toxicity or local skin irritation during the course of the study and no cases of mortality were observed. In this study Stimulation Indices (S.I.) of 1.43, 2.36, and 1.84 were determined with the test item at concentrations of 25, 50 (w/v), and 100% in acetone:olive oil (4+1 v/v), respectively.
The test item peroxidised corn oil was not a skin sensitiser under the test conditions of this study.
Migrated from Short description of key information:
Not sensitising to the skin (OECD 429, GLP)
Justification for classification or non-classification
Based on the classification criteria of Annex VI Directive 67/548/EEC or UN/EU GHS, and given the absence of positive reactions in a LLNA test, peroxidised corn oil is not classified as a skin sensitizer.
No data are available for respiratory sensitisation; therefore no conclusion can be made on the classification of this endpoint.
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