Registration Dossier
Registration Dossier
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EC number: 700-945-5 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The activated sludge respiration test with the test material passed the quality control criteria for an acceptable test. The EC50 was calculated to be greater than 10,000 mg/L.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 1 000 mg/L
Additional information
The potential impact of the test item on microbial metabolism, as represented by the consumption of oxygen, was investigated using the “Activated Sludge, Respiration Inhibition Test” as prescribed by OECD 1984 and detailed in OECD 209. The test was performed on March 10, 1994. The test duration was a three hour exposure period to the test material followed by up to ten minutes for the measurement of oxygen consumption. The study design was comprised of five nominal exposure concentrations: 1, 10, 100, 1,000, and 10,000 mg/L; a duplicate control group; and an assessment of the sensitivity of the inoculum used in the test to a reference toxicant 3,5-dichlorophenol. The activated sludge respiration test with the test item passed the quality control criteria for an acceptable test. The EC50 calculated for the reference toxicant was 5.0 mg/L within the acceptable range of 5 to 30 mg/L. The two control replicates produced oxygen consumption rates within the required 15% of each other, 30.0 and 28.2 mg O2/L*hr. The respiration rates of the sludge associated microbes exposed to the five nominal concentrations of the test item were 23.5, 22.5, 23.0, 23.4, and 28.9 mg O2/L*hr respectively. The EC50 was calculated to be greater than 10,000 mg/L.
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