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EC number: 205-238-0 | CAS number: 136-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium dibutyldithiocarbamate
- EC Number:
- 205-238-0
- EC Name:
- Sodium dibutyldithiocarbamate
- Cas Number:
- 136-30-1
- Molecular formula:
- C9H19NS2.Na
- IUPAC Name:
- sodium (dibutylcarbamothioyl)sulfanide
- Details on test material:
- - Name of test material (as cited in study report): Sodium dibutyldithiocarbamate (perkacit SDBC liq-w47%)
- Physical state: clear light yellow liquid
- Analytical purity: 46.20% (concentrated aqueous solution)
- Expiration date of the lot/batch: 19 April 2011 (allocated by NOTOX, 1 year after receipt of the test substance)
- Stability under test conditions: stable
- Storage condition of test material: at room temperature in the dark under nitrogen
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland, Sulzfeld, Germany
- Age at study initiation: approx. 8-12 weeks old
- Weight at study initiation: +/- 20% of the sex mean
- Fasting period before study: overnight
- Housing: group housing of 3 animals per cage in labeled Macrolon cages (MIV type; height 18 cm) containing sterilized sawdust as bedding material (Litalabo, S.P.P.S., Argenteuil, France) and paper as cage-enrichment (Enviro-dri, Wm. Lillico & Son (Wonham Mill Ltd), Surrey, United Kingdom)
- Diet: pelleted rodent diet (SM R/M-Z from SSNIFF® Spezialdiäten GmbH, Soest, Germany), ad libitum
- Water: tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19.6 – 21.5
- Humidity (%): 38 - 75
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 46.20%
- Amount of vehicle: 1.887 mL/kg bw (2000 mg/kg bw) and 0.283 mL/kg bw (300 mg/kg bw)
- Justification for choice of vehicle: substance as manufactured and marketed - Doses:
- 300 and 2000 mg/kw bw
- No. of animals per sex per dose:
- 6 females/dose (in two groups of 3 females)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals were observed twice daily for mortality. Body weights were determined at Days 1 (pre-administration), 8 and 15 and at death (if found dead after Day 1).
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: According to the OECD 423 test guideline, the LD50 cut-off value was considered to be 1000 mg/kg body weight. The value is determined for 46.2% solution of the substance; recalculated for pure substance it corresponds to LD50 of 141-940 mg/kg bw.
- Mortality:
- In the first group, treated with 2000 mg/kg bw test substance, 1 female died. In the second group administered the same dose all 3 animals died. Deaths occurred at days 1 or 2 post-treatment.
- Clinical signs:
- other:
- Body weight:
- other body weight observations
- Remarks:
- The body weight gain shown by the surviving animals over the study period was considered to be similar to that expected of normal untreated animals of the same age and strain.
- Gross pathology:
- Upon macroscopic post mortem examination, several reddish or many dark red foci were found in the stomach glandular mucosa of all animals at 2000 mg/kg that were found dead during the study. Cannibalism and beginning autolysis were noted for one of these animals at necropsy. Macroscopic post mortem examination of the surviving animals at termination did not reveal any abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- This is applicable for the 47% aqueous solution of SDMC.
- Executive summary:
No data on acute toxicity of pure SDBC are available. The acute oral toxicity studies with SDBC as a 46% solution in water were used. In an OECD 423, GLP study in rats (Notox 2010), SDBC was given orally by gavage at 300 and 2000 mg/kg bw. In the first group, treated with 2000 mg/kg bw, 1 female died. In the second group administered the same dose all 3 animals died. Deaths occurred at days 1 or 2 post-treatment. Lethargy, tremor of the head, general muscle twitching, hunched posture, uncoordinated movements, piloerection and ptosis were observed. The surviving animals at 2000 mg/kg had fully recovered from the symptoms by Day 3. Hunched posture and/or piloerection were also noted among the animals at 300 mg/kg which had fully recovered from the symptoms by Day 3. Upon macroscopic post mortem examination, several reddish or many dark red foci were found in the stomach glandular mucosa of all animals at 2000 mg/kg that were found dead during the study. Cannibalism and beginning autolysis were noted for one of these animals at necropsy. Macroscopic post mortem examination of the surviving animals at termination did not reveal any abnormalities. The LD50 values were between 300 and 2000 mg/kg bw. The average of 2 dead animals per set of 3 treated animals at 2000 mg/kg was used for the assessment of the LD50 cut-off value. The LD50 cut-off value was considered to be 1000 mg/kg bw. Calculated for the isolated (anhydrous) substance, this corresponds to LD50 of 141-940 mg/kg bw. However, the lower limit of this range is meaningless for classification and labeling purposes for the pure substance.
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