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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Two reliable studies (Kynoch and Mihail) for skin irritation/corrosion are available. Both studies didn't fully comply with actual guidelines - but these studies are sufficient for evaluation and classification by a weight of evidence consideration.
In the study by Kynoch, 6 rabbits were treated for 24 hours with 500 µl of dibenzylether. Scoring was made after 24 and 72 hours. In the study by Mihail, 2 rabbits were treated with 500 µl at the inside of the rabbit ears. Exposition time was 24 h, fixation of test substance by plaster. After exposition the test-substance was removed with water and soap/plant oil, post-observation period was 7 days. The evaluation of the skin damages was performed according to Draize.
Two reliable studies (Kynoch and Mihail) for eye irritation similar to actual OECD guideline are available.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation:

There are two reliable studies reported for the skin irritation potential of dibenzyl ether.

In both cases, skin irritation has been assessed after a 24 hour exposure period. In the Kynoch study erythema and edema score was measured 24 and 72 hours after application of the test substance. On intact skin mean erythema score was 0.66 intact skin and on abraded skin 0.83. The mean edema score was 0.75 on intact skin and 0.91 on abraded skin. Score values of later time-points are not available. In the study by Mihail erythema score immediately after the removal of the test substance was = 0.5 and = 0 after 48 hours. The edema score was = 0 after 0 hours (immediately after removal test substance) and after 48 hours. The findings were reversible within 48 hours. Therefore a classification is not justified.

Eye irritation:

There are two reliable studies reported for the eye irritation potential of dibenzyl oxide.

In both cases, eye irritation has been assessed after a 24 hour exposure period. In the Kynoch study cornea and iris score were = 0 at 24, 48 and 72 hours. The conjunctiva score was 0.72 (fully reversible within 7 days and the chemosis score = 0.15 (fully reversible within 3 day) both measured after 24, 48 and 72 hours. In the study by Mihail the cornea and chemosis score was = 0 at 24, 48 and 72 hours; the iris score was 0.66 after 24, 48 and 72 hours (reversible within 3 days). The conjunctiva score was not reported.

Based on the studies by Kynoch and Mihail a classification is not justified.


Justification for selection of skin irritation / corrosion endpoint:
Two reliable studies (Kynoch and Mihail) are available. Both studies didn't fully comply with actual guidelines - but these studies are sufficient for evaluation and classification by a weight of evidence consideration.

Justification for classification or non-classification

Skin irritation:

Based on the reliable studies by Kynoch and Mihail a classification is not justified on a weight of evidence consideration.

Eye irritation:

Based on the reliable studies by Kynoch and Mihail a classification is not justified.