Registration Dossier
Registration Dossier
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EC number: 414-240-2 | CAS number: 6914-71-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EC B.14 / Ames-Test
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: Salmonella typhimurium TA 98, 100, 1535, 1537, 1538
- Metabolic activation system:
- S9-mix
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 8 ... 5000 µg/plate
Concentration range in the main test (without metabolic activation): 8 ... 5000 µg/plate - Vehicle / solvent:
- Solvent: DMSO
Results and discussion
- Additional information on results:
- Observations:
CDM has no mutagenic effects to all test strains in presence
and absence of S9-mix and is also not mutagene in the
preincubation test.
No toxic effects appeared.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
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