Registration Dossier
Registration Dossier
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EC number: 606-524-1 | CAS number: 203313-47-7
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 1989
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- methyl cis-1-{[(2,5-dimethylphenyl)acetyl]amino}-4-methoxycyclohexanecarboxylate
- EC Number:
- 606-524-1
- Cas Number:
- 203313-47-7
- Molecular formula:
- C19H27NO4
- IUPAC Name:
- methyl cis-1-{[(2,5-dimethylphenyl)acetyl]amino}-4-methoxycyclohexanecarboxylate
- Test material form:
- solid: bulk
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficientopen allclose all
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.3
- Temp.:
- 40 °C
- pH:
- 7
- Type:
- Pow
- Partition coefficient:
- 200
- Temp.:
- 40 °C
- pH:
- 7
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient (1-octanol / water) of the test item was at 40 °C and pH 7: log POW 2.3; POW 200.
- Executive summary:
The partition coefficient (1-octanol/water) of AE 1302941 was determined according to the OECD guideline 117, EEC guideline 92/69/EEC A.8. and EPA Products Properties Guideline OPPTS 830.7570 (HPLC-method).
Nine calibration substances were injected into an HPLC-system under the same analytical conditions as the test item at 40 °C column temperature. Neutral calibration substances were used. Calibration curves were created by using the measured retention times (log k’-values) and the known log POW-values of the calibration substances for linear regression.
The measured log k’-values of the test item were within the calibrated log k’-range.
From the resulted calibration curves and their equations the log POW-value of the test item was interpolated.
The partition coefficient (1-octanol / water) of the test item was at 40 °C:
pH 7 log POW 2.3 POW 200
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