L-aspartic acid, sodium salt

Density

Administrative data

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2022

Report date:

2022

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Principles of method if other than guideline:

The particle size analysis test was performed in accordance to a test procedure no. SPO/BF/24/b (ed. 4) based in CIPAC MT 187 (and ISO 13320:2020) using Coulter LS 13 320 with ULM (Universal Liquid Model).
A representative sample of the test item is dispersed at an adequate concentration in a suitable liquid, is passed through the beam of a monochromatic light source, a laser. The light
scattered by the particles at various angles is measured by a multi-element detector and numerical, values relating to the scattering pattern are then recorded for subsequent analysis. These numerical scattering values are then transformed, using an appropriate optical model and mathematical procedure, to yield the proportion of total volume to a discrete number of size classes forming a volumetric particle size distribution.

GLP compliance:

yes (incl. QA statement)

Type of method:

pycnometer method

Test material

Test material information

Constituent 1

Reference substance name:

sodium 2-amino-3-carboxypropanoate

Cas Number:

323194-76-9

Molecular formula:

C4H7NO4.xNa

IUPAC Name:

sodium 2-amino-3-carboxypropanoate

Test material form:

solid: particulate/powder

Details on test material:

Name: L-aspartic acid, sodium salt monohydrate 1
Batch/Lot number: Z201125/ VG29848563
CAS number: 323194-76-9
Anhydrous substance name: L-aspartic acid, sodium salt, CAS: 17090-93-6
Appearance: Solid, white, crystalline powder
Purity: 98%
Expiry date: 24 November 2022
Storage conditions: Room temperature (15-25 ºC), protected from humidity (tight closed
container)

Results and discussion

Density

Density 1

Key result

Type:

density

Density:

ca. 1.732 g/cm³

Temp.:

20 °C

Density 2

Key result

Type:

relative density

Density:

ca. 1.732 other: na

Temp.:

20 °C

Applicant's summary and conclusion

Conclusions:

The average measured absolute density at 20 ºC temperature was 1.7320 g/ml
The average calculated relative density at 20 ºC temperature was 1.7320.

Executive summary:

The average measured absolute density at 20 ºC temperature was 1.7320 g/ml

The average calculated relative density at 20 ºC temperature was 1.7320.

Determination of density was carried out in accordance with Standard Operating Procedure SPO/BF/01/b (ed. 6) based on OECD 109 “Density of Liquids and Solids”.

The volume of the Gay-Lussac pycnometer (ISO 3507:1999) was measured using Standard Water of purity 3 (ISO 3696: 1999) of a defined density (ISO 649/2 E).

The test was performed at 20 °C temperature. The density is calculated by dividing the weight of the tested material by its volume in immersing liquid (the tested material was found to be insoluble in tert-butyl methyl ether MTBE). The average of two measurements which were within the range of the estimated accuracy will be considered.