Registration Dossier
Registration Dossier
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EC number: 827-772-9 | CAS number: 20650-07-1
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (3-methoxypropyl)dimethylamine
- EC Number:
- 827-772-9
- Cas Number:
- 20650-07-1
- Molecular formula:
- C6H15NO
- IUPAC Name:
- (3-methoxypropyl)dimethylamine
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- At t=0 and 48 hours
Test solutions
- Vehicle:
- no
- Details on test solutions:
- 0.11, 1.1, 12 and 112 mg/L (geometric mean measured concentrations)
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 20-21°C
- pH:
- 7.7-8.2: test-item dependent increase in pH
- Nominal and measured concentrations:
- The measured concentrations at the start and at the end of the test were mostly in agreement with the nominal concentrations, i.e. were at 108-124% relative to the nominal concentrations at both time points.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 112 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 112 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- no immobile daphnid at any concentration
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
In a static test, Daphnia magna EC50(48h) and NOEC(48h) were both above 112 mg/L, based on geometric mean measured concentrations.
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