Registration Dossier
Registration Dossier
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EC number: 403-610-9 | CAS number: 122795-41-9
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The acute toxicity of Neoproxen to Daphnia magna was assessed under static conditions in a GLP study according to OECD Guideline No. 202. Daphnia were exposed to test concentrations of 1.0, 1.8, 3.2, 5.6, 10, 18, 32, 56 and 100 mg/L.
Verification of test concentrations showed that the test concentrations showed a marked decline in test concentrations over a 48 -hour period. The average of the 48-hour "percentage of nominal values" (i.e. 46%) was used as a correction factor for the nominal test concentration to enable calculation of the EC50. The 48 h EC50 was 5.8 mg/L with 95% confidence limits of 4.6 - 7.4 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 5.8 mg/L
Additional information
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