Registration Dossier
Registration Dossier
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EC number: 922-223-0 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Oligomerisation products of 2-(chloromethyl)oxirane and 2-ethyl-2-(hydroxymethyl)propane-1,3-diol
- EC Number:
- 922-223-0
- Molecular formula:
- not applicable for UVCB
- IUPAC Name:
- Oligomerisation products of 2-(chloromethyl)oxirane and 2-ethyl-2-(hydroxymethyl)propane-1,3-diol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- In the 2000 mg/kg B.W. (3nd step) 1 animal dead at Day 1 after administration were observed. No dead animals were observed in the 300 mg/kg B.W. (1st, 2nd step) and 2000 mg/kg B.W. (4th step) test substance administration groups.
- Clinical signs:
- other: All animal in the 2000 mg/kg (3rd step) test substance group from 2 hours to 4 hours after administration clinical signs were observed soiled perineal region, diarrhea and one animal were dead at Day 2 after administration. Also, one animal was recovered
- Gross pathology:
- In necropsy of dead animal at 2000 mg/kg B.W. (3rd step) test substance administration group, soiled perineal region was observed in one animal. In survived animals in 300 mg/kg B.W. (1st, 2nd step), 2000 mg/kg B.W. (4th step) and the other two survived animals in 2000 mg/kg B.W. (3th step) were no lesions caused by administration of test substance.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
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