Registration Dossier
Registration Dossier
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EC number: 943-705-7 | CAS number: 947686-05-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 431 (In Vitro Skin Corrosion: Human Skin Model Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3',5-bis(prop-2-en-1-yl)-[1,1'-biphenyl]-2,4'-diol; 5,5'-bis(prop-2-en-1-yl)-[1,1'-biphenyl]-2,2'-diol
- Cas Number:
- 947686-05-7
- Molecular formula:
- C18H18O2
- IUPAC Name:
- 3',5-bis(prop-2-en-1-yl)-[1,1'-biphenyl]-2,4'-diol; 5,5'-bis(prop-2-en-1-yl)-[1,1'-biphenyl]-2,2'-diol
- Test material form:
- solid
Constituent 1
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- % tissue viability
- Value:
- >= 11.9
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Irritation / corrosion parameter:
- % tissue viability
- Value:
- >= 113.6
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Magnolia Officinalis Bark Extract is considered non-corrosive to skin in the Reconstructed Human Epidermis (RHE) Test Method.
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