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EC number: 700-235-5 | CAS number: 174899-82-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://www.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 2017 - 10 November 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 17 December 2001
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Version / remarks:
- Council regulation No. 440/2008
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 1-ethyl-3-methyl-1H-imidazol-3-ium; trifluoro[(trifluoromethanesulfonylazanidyl)sulfonyl]methane
- EC Number:
- 700-235-5
- Cas Number:
- 174899-82-2
- Molecular formula:
- C8H11F6N3O4S2
- IUPAC Name:
- 1-ethyl-3-methyl-1H-imidazol-3-ium; trifluoro[(trifluoromethanesulfonylazanidyl)sulfonyl]methane
- Test material form:
- liquid
- Details on test material:
- clear liquid, colorless
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: proionic GmbH; 25PI208_12; PA 177
- Expiration date of the lot/batch: May 2019
- Purity test date: > 99%w
STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elevage JANVIER LABS (53940 Le Genest St Isle - France)
- Females nulliparous and non-pregnant: yes
- Age at study initiation: 8 weeks
- Weight at study initiation: ~ 200 grams
- Housing: solid-bottomed clear polycarbonate cages with a stainless stell mesh lid; sawdust bedding
- Diet (e.g. ad libitum): foodstuff (ENVIGO - 2016)
- Water (e.g. ad libitum): tap-water from public distribution system
- Acclimation period: at least five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19°C - 25°C
- Humidity (%): 30 to 70
- Air changes (per hr): at least 10
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- other: administered under a volume of 1.32 mL/kg body weight using a suitable syrine graduated with an oesophageal metal canula
- Vehicle:
- DMSO
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 0.20 mL test item in 1.12 mL DMSO (corresponding to 300 mg)
0.033 mL test item in 1.287 mL DMSO (corresponding to 50 mg)
0.066 mL test item in 2.574 mL DMSO (corresponding to 100 mg)
- Justification for choice of vehicle: most suitable formulation possible
MAXIMUM DOSE VOLUME APPLIED: each preparation was administered under a volume of 1.32 mL/kg body weight
- Doses:
- 50 mg/kg and 300 mg/kg
- No. of animals per sex per dose:
- Group treated (300 mg/kg): 3 female rats Rf1622 to Rf1624 (Step 1)
3 female rats Rf1638 to Rf1640 (Step 2)
Group treated (50 mg/kg): 3 female rats Rf1648 to Rf1650 (Step 3)
3 female rats Rf1662 to Rf1664 (Step 4) - Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 30 min, 1h, 3h, 4h, 24h, 48 h after administration of the test item and continued daily during 14 days; The animals were weighted on day D0 (just before administering the test item) then on day 2, day 7 and day 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical observations; body weight evolution; macroscopic examinations
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 50 - < 300 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 3 mortalities at the dose of 300 mg/kg body weight
- Clinical signs:
- other: absence in spontaneous activity, muscle tones, righting reflex, Preyer´s reflex, chronic convulsion, associated with an increase of and salivation, mydriasis, dyspnea or polypnea
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The LD50 of the test item 1-Ethyl-3-methylimidazolium bis (trifluoromethylsulfony)imide is higher than 50 mg/kg and lower than 300 mg/kg by oral route in the rat.
In accordance with the O.E.C.D Test Guideline No. 423, the LD50-cut-off of the test item may be considered as 300 mg/kg body weight by oral route in the rat.
According to the criteria for classification, packaging and labelling of dangerous substances and preperations in accordance with the regulation EC No. 1272/2008, the test item 1-Ethyl-3-methylimidazolium bis (trifluoromethylsulfonyl)imide has to be classified in the category 3. The signal word "DANGER" and hazard statement H301 "Toxic if swallowed" are required - Executive summary:
The test item 1 -Ethyl-3 -methylimidazolium bis(trifluoromethylsulfonyl)imide was administered to a group of 6 female Spreque Dawley rats at the dose of 300 mg/kg body weight and the to a group of 6 female Spraque Dawley rats at the dose of 50 mg/kg body weight. The experimental protocol was established according to the official method as defined in the O.E.C.D Test Guideline No. 423 dated December 17th, 2001 and the test method B.1tris of the Council regulation No. 440/2008.
Three mortalities were noted in animals treated at the dose of 300 mg/kg body weight, one at 3 hours post dose during the 1st step and two at 24 hours post dose during the 2nd step.
The mortalities were preceded by an absence in spontaneous activity, muscle tones, righting reflex, Preyer´s reflex, chronic convulsion, associated with an increase of and salivation, mydriasis, dyspnea or polypnea.
Rigor mortis (1/3) were noted before the necropsy.
The macroscopic examination of these animals revealed a colorless liquid inside the stomach (1/3). No other change was noted.
In the surviving animals (3/6), a decrease or absence in spontaneaous activity, muscle tones, righting reflex, chronic convulsion, Preyer´s reflex, associated with an increase of salivation, mydriasis or myosis, and eyes partially / totally closed were noted at 30 minutes pot dose. The animal recovered a normal activity on day 2.
An asence of body weight gain was noted on day 2 versus day 0. Then, the body weight evolution of the animals remained normal.
The macroscopic examination of the animals at the end of the study did not reveal treatment related changes.
No mortality was noted in the animals treated at the dose of 50 mg/kg body weight.
No clinical signs related to the administration of the test item were observed during the study.
The body weight evolution of the animals treated at the dose of 50 mg/kg body weight remained normal during the study.
The macroscopic examination of the animals treated at the dose of 50 mg/kg body weight at the end of the study did not reveal treatment related changes.
In conclusion, the LD50 of the test item 1-Ethyl-3-methylimidazolium bis (trifluoromethylsulfony)imide is higher than 50 mg/kg and lower than 300 mg/kg by oral route in the rat.
In accordance with the O.E.C.D Test Guideline No. 423, the LD50-cut-off of the test item may be considered as 300 mg/kg body weight by oral route in the rat.
According to the criteria for classification, packaging and labelling of dangerous substances and preperations in accordance with the regulation EC No. 1272/2008, the test item 1-Ethyl-3-methylimidazolium bis (trifluoromethylsulfonyl)imide has to be classified in the category 3. The signal word "DANGER" and hazard statement H301 "Toxic if swallowed" are required
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