6-Amino-5-chloro-2-cyclopyrimidine-4-carboxylic acid

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

substances / mixtures which in contact with water emit flammable gases

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the experience in production or handling shows that the substance does not react with water, e.g. the substance is manufactured with water or washed with water

Reference 2

Endpoint:

pyrophoric solids

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is known to be stable in contact with air at room temperature for prolonged periods of time (days) and hence, the classification procedure does not need to be applied

Reference 3

Endpoint:

self-heating substances / mixtures

Data waiving:

other justification

Justification for data waiving:

other:

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING
The available data on self-heating properties of the test substance do not meet the criteria for classification according to Regulation (EC) 1272/2008 and are therefore conclusive but not sufficient for classification:
The classification procedure for self-heating substances or mixtures needs not be applied if the results of a screening test can be adequately correlated with the classification test and an appropriate safety margin is applied. An example of screening tests is the Grewer Oven test (VDI guideline 2263, part 1, 1990, Test methods for the Determination of the Safety Characteristics of Dusts). The EU A.16 test performed with the substance results in no exothermic effects up to 400 °C, what can be interpreted in analogy to the Grewer Oven test. Therefore the substance is not self-heating on the basis of the screening test and the classification test N.4 in Part III, subsection33.3.1.6 of the UN-MTC, need not be performed.

Reason / purpose for cross-reference:

data waiving: supporting information

Reference 4

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2007-09-12 to 2007-09-28

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.10 (Flammability (Solids))

GLP compliance:

yes

Key result

Test procedure:

burning rate test: preliminary screening test

Remarks on result:

substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period

The test substance was not found to support combustion in the initial screening test. Only local melting and burning at the point of flame application was observed. Since no propagation of the product train occurred within a time specified in the method, there was no need for conducting a full program including six additional burning rate tests to establish a precise burning rate for the test substance.

The test item is not a flammable solid.

Conclusions:

The substance is not a flammable solid: the substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period (EU Method A.10)

Description of key information

non flammable

not pyrophoric

no flammability on contact with water

not self-heating

Key value for chemical safety assessment

Flammability:

not classified

Additional information

No ignition in the preliminary burning rate test (EU Method A.10).

Based on experience in handling and use pyrophoricity and flammability on contact with water are not to be expected.

No exothermic effects up to 400 °C was observed in a study according to EU Method A.16, what can be interpreted in analogy to the Grewer Oven test. Therefore, the substance is not self-heating on the basis of the screening test and the classification test N.4 in Part III, subsection 33.3.1.6 of the UN-MTC, need not be performed.

Justification for classification or non-classification

The available data on flammability of the test substance do not meet the criteria for classification according to Regulation (EC) 1272/2008, and are therefore conclusive but not sufficient for classification:

No ignition in the preliminary burning rate test (EU Method A.10).

Based on experience in handling and use pyrophoricity and flammability on contact with water are not to be expected.

No exothermic effects up to 400 °C was observed in a study according to EU Method A.16, what can be interpreted in analogy to the Grewer Oven test. Therefore, the substance is not self-heating on the basis of the screening test and the classification test N.4 in Part III, subsection 33.3.1.6 of the UN-MTC, need not be performed.