Registration Dossier
Registration Dossier
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EC number: 437-450-6 | CAS number: -
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 29 July 1999 and 15 December 1999.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- No further details specified in the study report.
- Dissociating properties:
- not determined
- Remarks on result:
- other: estimate using chemical stucture: 1.64 pKa
- Conclusions:
- An estimate of the dissociation constant was made using the chemical structure of APAN and a Hammett type equation.
The estimate of pKa was 1.64 ± 0.20. - Executive summary:
Method 112 of the OECD Guidelines for Testing of Chemicals, 12 May 1981, was not applicable to APAN. An estimate of pKa (1.64 ± 0.20) was made using a Hammett type equation.
Reference
An estimate of the dissociation constant was made using the chemical structure of APAN and a Hammett type equation.
The estimate of pKa was 1.64 ± 0.20.
Description of key information
An estimate of pKa (1.64 ± 0.20) was made using a Hammett type equation.
Key value for chemical safety assessment
- pKa at 20°C:
- 1.64
Additional information
Method 112 of the OECD Guidelines for Testing of Chemicals, 12 May 1981, was not applicable to APAN. An estimate of pKa (1.64 ± 0.20) was made using a Hammett type equation.
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