Registration Dossier
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EC number: 272-897-9 | CAS number: 68919-40-4
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Remarks:
- solubility in n-octanol
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 18, 2018 - March 14, 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: EC A.6. method (2014) and OECD Guideline No. 105 (1995)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Key result
- Medium:
- n-octanol
- Solubility:
- >= 51.6 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: determined from the quantitative analysis of C12 amphopropionic acid
- Key result
- Medium:
- n-octanol
- Solubility:
- >= 50.6 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: determined from the quantitative analysis of acrylic acid
- Conclusions:
- The solubility in n-octanol of the test item at 20.0°C ± 2.0°C was determined to be ≥ 50.6 -51.6 g/L from the quantitative analysis in the test solutions of its main constituents, C12 amphopropionic acid and acrylic acid.
- Executive summary:
The solubility in n-octanol of the test item was investigated in a GLP-compliant study performed in accordance with an adaptation of EU Method A.6 (Water Solubility) and OECD Guideline 105 (Water Solubility). The solubility in n-octanol of the test item at 20.0°C ± 2.0°C was determined to be ≥ 50.6 -51.6 g/L from the quantitative analysis in the test solutions of its main constituents, C12 amphopropionic acid and acrylic acid.
Reference
PRELIMINARY TEST
Through the serial volume addition of n-octanol to the test item, the following table shows the solubility in n-octanol of the test item at 20.0 °C ± 2.0 °C.
| Weight of the test item (g) | Volume of n-octanol (mL) | Solubility* (g/L) | |
| 0.11842 | 0.1 | No | / |
| 0.5 | No | / | |
| 1 | No | / | |
| 2 | No | / | |
| 10 | No | / | |
| 0.10527 | 100 | Yes | 1 -10 |
*Solubility:
No: Undissolved material was visually observable in the test solution.
Yes: No undissolved material was visually observable in the test solution.
Description of key information
The solubility in n-octanol of the test item was investigated in a GLP-compliant study (Ricau, 2019) performed in accordance with an adaptation of EU Method A.6 (Water Solubility) and OECD Guideline 105 (Water Solubility). The solubility in n-octanol of the test item at 20.0°C ± 2.0°C was determined to be ≥ 50.6 -51.6 g/L from the quantitative analysis in the test solutions of its main constituents, C12 amphopropionic acid and acrylic acid.
Key value for chemical safety assessment
- Solubility in organic solvents at 20°C:
- 50.6 mg/L
Additional information
The solubility in n-octanol of the test item was investigated in a GLP-compliant study (Ricau, 2019) performed in accordance with standard methods, without deviations. The study is considered as reliable without restriction (Klimisch 1) and was selected as key study for the endpoint.
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