Registration Dossier
Registration Dossier
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EC number: 940-222-3 | CAS number: 1403893-61-7
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 August 2012 to 29 August 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Other quality assurance:
- other: inspected by WIL research
- Type of method:
- effusion method: isothermal thermogravimetry
Test material
- Reference substance name:
- 4-chloro-6-ethenyl-5-fluoropyrimidine
- EC Number:
- 940-222-3
- Cas Number:
- 1403893-61-7
- Molecular formula:
- C6 H4 Cl F N2
- IUPAC Name:
- 4-chloro-6-ethenyl-5-fluoropyrimidine
- Test material form:
- liquid
- Details on test material:
- received as orange brown liquid
Constituent 1
- Specific details on test material used for the study:
- Batch JZ10F-7-40 Purity/Composition 97.6% (HPLC) Test substance storage In refrigerator (2-8°C) in the dark Stability under storage conditions Stable Expiry date 31 December 2012
Results and discussion
Vapour pressureopen allclose all
- Key result
- Test no.:
- #1
- Temp.:
- ca. 20 °C
- Vapour pressure:
- ca. 0.78 mm Hg
- Key result
- Test no.:
- #2
- Temp.:
- ca. 25 °C
- Vapour pressure:
- ca. 1.3 mm Hg
Applicant's summary and conclusion
- Conclusions:
- The isothermal TGA effusion method was applied for the determination of the vapour pressure of PF-06645243; 4-Chloro-5-fluoro-vinylpyrimidine; CFVP.
The vapour pressure of the test substance at 20°C (293K) and 25°C (298K) was:
20oC 20oC 25oC 25oC
[Pa] [mm Hg] [Pa] [mm Hg]
Test substance 1.0 x 10e2 0.78 1.8 x 10e2 1.3
- Executive summary:
Parameter Guideline(s) Result Comment
Vapour pressure EC A.4 OECD 104 OPPTS 830.7950 20°C 1.0 x 10e2 Pa = 0.78 mm Hg isothermal TGA effusion method
25°C 1.8 x 10e2 Pa = 1.3 mm Hg
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