Registration Dossier
Registration Dossier
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EC number: 202-987-5 | CAS number: 101-90-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 January 2018 - 24 March 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- - Source and lot/batch No.of test material: 53715080
- Storage condition of test material: Room temperature in the dark - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. 28.7
- Temp.:
- 30 °C
- pH:
- ca. 5.7
- Details on results:
- The result from the preliminary estimate indicated that the HPLC method was suitable for determination of the partition coefficient. As the test item does not contain any modes of dissociation, testing was performed at approximately neutral pH with the test item in a non-ionized form. The main component in the chromatography was determined to be approximately 88% by area percentage normalization This is consistent with the test item being a mono-constituent and as such, the partition coefficient of the main peak has been reported.
- Conclusions:
- The partition coefficient of the test item has been determined to be 28.7, log10 Pow 1.46.
Reference
Description of key information
The partition coefficient of the test item has been determined to be 28.7, log10 Pow 1.46.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.46
- at the temperature of:
- 20 °C
Additional information
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