Registration Dossier
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EC number: 212-216-4 | CAS number: 770-05-8
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 July 2018 to 22 August 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Sponsor and D151-1710037
- Expiration date of the lot/batch: 26 October 2019 (retest date)
- Purity test date: 27 October 2017 - Key result
- Melting / freezing pt.:
- 173.8 °C
- Atm. press.:
- ca. 1 atm
- Conclusions:
- The melting temperature of Octopamine hydrochloride were determined by DSC.
The melting temperature of the test item was 173.8°C (447.0K)
Reference
Preliminary Test
The TGA curve of the test item is shown inFigure 1. Starting at 175°C, the weight of the sample decreased significantly. At 327°C, the sample weight had decreased by 25%.
After the experiment, a black molten residue remained in the sample container (original colour: white) and a black residue was observed on the lid of the sample container. The change of the colour indicated reaction and/or decomposition of the test item.
Main Study
The DSC curve obtained with Experiment 1 is shown inFigure 2. An endothermic effect was observed starting at 150°C and directly followed by a strong exothermic effect and an endothermic effect. The extrapolated onset temperature of the first effect was 173.852°C. The endothermic effect was most likely obtained due to melting of the test item.
After the experiment, a black molten residue remained in the sample container (original colour: white) and a black residue was observed on the lid of the sample container. The change of the colour indicated reaction and/or decomposition of the test item. Based on this visual observation, it was found that the test item had molten and the change of the colour demonstrated reaction and/or decomposition of the test item.
In order to investigate theendothermiceffect, Experiment 2 was stopped directly after the melting effect. Figure 3shows the DSC curve obtained. Theextrapolated onset temperature was 173.829°C. After the experiment, a brown molten residue remained in the sample container (original colour: white) and a black residue was observed on the lid of the sample container. Based on this visual observation, it was found that the test item had molten and the change of the colour demonstrated reaction and/or decomposition of the test item.
The melting temperature was determined as the mean melting temperature of Experiment 1 (173.852°C) and Experiment 2 (173.829°C).
Description of key information
The melting temperature of Octopamine hydrochloride were determined by DSC. The melting temperature of the test item was 173.8°C (447.0K)
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 173.8 °C
Additional information
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