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EC number: 238-056-5 | CAS number: 14205-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 October 1999 - 23 March 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- Feb. 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Version / remarks:
- July 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Version / remarks:
- August 1998
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Test material form:
- solid
- Details on test material:
- Expiry date: 21 May 2000
Batch: 624
Constituent 1
- Specific details on test material used for the study:
- White crystalline solid stored in the dark at ambient temperature.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Five male and 5 female (nulliparous and non-pregnant) young adult rats of the Sprague-Dawley strain were used. They were approximately 8 weeks old and
weighed 164-230 g on arrival. They were supplied by Harlan UK and arrived at lnveresk Research on 20 October 1999. The animals were allowed to acclimatise for 8 days prior to commencement of the study. The animals were housed individually in suspended polypropylene cages (dimensions 42 x 27 x 20 em), with stainless steel grid tops and bottoms, suspended over absorbent paper lined trays.
Each cage was supplied with a stainless steel food hopper and polypropylene water bottle with cap and stainless steel nozzle.
Mean environmental maximum and minimum temperatures were 22°C and 19°C, and the mean relative humidity was 48%. A 12 h light/dark cycle was in
operation (light hours 0700-1900 h) with a minimum of 15 air changes per hour.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 10 (5 male and 5 females)
- Control animals:
- no
- Details on study design:
- The test material was administered topically in a single 24 h application, under occlusion as follows:
One day prior to test material application the dorsal area of the trunk of each rat was clipped free of hair (approximately 7 cm x 8 cm),
taking care to avoid abrading the skin. On the following day, the appropriate quantity of finely ground test material,
which was calculated to be approximately 41 mg.cm-2 was applied onto the water moistened dorsal skin and spread uniformly over the trunk
(approximately 4% of the total body surface). The test material was then covered b,t a water moistened gauze patch (5 cm x 6 cm), secured with
Micropore (3M Medical-Surgical Division, USA) semi-occlusive tape, and a strip of non-irritating occlusive tape (Sleek, Smith and Nephew Medical
Limited, USA) wound round the trunk. The dose was calculated based on the weight of the animal on the day of dosing.
After a contact period of 24 h the patches were removed and the test sites delineated. The skin was then wiped with sterile distilled water. - Statistics:
- No formal statistical analysis was conducted.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no premature decedents during the study.
- Clinical signs:
- other: On the day of dosing, clinical signs were limited to red discharge from the eyes and nose. Other clinical signs noted were dry flaky skin and/or scabbing from Day 6 up to Day 15. A wet perigenital area was noted in 2 of the female animals on Day 2 only.
- Gross pathology:
- Dry, red, scabbing on the dorsal surface was noted in 2 female animals.
- Other findings:
- No other abnormalities were noted in the remaining animals.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the study, the Median Dermal Lethal Dose (LD50) of LZ937 in Sprague-Dawley rats is estimated to be greater than 2000 mg/kg bw.
- Executive summary:
A acute dermal toxicity study was performed in year 1999/2000 according to OECD Guideline 402 and GLP. One group of 5 male and 5 female rats was exposed to a 24 h dermal
application of 2000 mg/kg b.w.. The test material was applied topically to the water moistened dorsal trunk of each animal under water moistened occlusive patches.
The animals were observed daily for viability and signs of reaction to treatment for up to 14 days after dosing. There were no premature decedents or major clinical signs noted during the
study. Body weight performance was generally considered to have been satisfactory, and there were no major findings noted at necropsy.
Under the conditions of the study, the Median Dermal Lethal Dose (LD50) of LZ937 in Sprague-Dawley rats is estimated to be greater than 2000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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