Phenol, 4,4'-(1-methylethylidene)bis-, oligomer with (chloromethyl)oxirane and ethylenediamine, reaction products with carbon disulphide, potassium salts

Biodegradation in water: screening tests

Administrative data

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

Assessed by modelling for short term and long term biodegradation potential

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Justification for type of information:

Although the adequacy of the modelling method is questionable, there is a safe prediction of low biodegradation.
The assessment suggests not-readily biodegradable to allow classification and labelling.
Further work is required for higher tonnage band to allow CSR to be prepared

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Use of QSAR - EPISuite BIOWIN

Test material

Test material information

Constituent 1

Reference substance name:

Phenol, 4,4'-(1-methylethylidene)bis-, oligomer with (chloromethyl)oxirane and ethylenediamine, reaction products with carbon disulphide, potassium salts

EC Number:

600-775-0

Cas Number:

1067676-04-3

IUPAC Name:

Phenol, 4,4'-(1-methylethylidene)bis-, oligomer with (chloromethyl)oxirane and ethylenediamine, reaction products with carbon disulphide, potassium salts

Test material form:

liquid

Details on test material:

Technical grade, CA 50% in water

Study design

Oxygen conditions:

aerobic

Results and discussion

% Degradation

Remarks on result:

not readily biodegradable based on QSAR/QSPR prediction

Any other information on results incl. tables

Probability of Rapid Biodegradation (BIOWIN v4.10):

  Biowin1 (Linear Model)         :   1.8270

  Biowin2 (Non-Linear Model)     :   0.9841

Expert Survey Biodegradation Results:

  Biowin3 (Ultimate Survey Model):   1.0561  (recalcitrant)

  Biowin4 (Primary Survey Model) :   3.1156  (weeks       )

MITI Biodegradation Probability:

  Biowin5 (MITI Linear Model)    :   0.1335

  Biowin6 (MITI Non-Linear Model):   0.0001

Anaerobic Biodegradation Probability:

  Biowin7 (Anaerobic Linear Model):  0.2045

Ready Biodegradability Prediction:   NO

Applicant's summary and conclusion

Interpretation of results:

inherently biodegradable, not fulfilling specific criteria

Conclusions:

Although the adequacy of the modelling method is questionable, there is a safe prediction of low biodegradation.
The assessment suggests not-readily biodegradable to allow classification and labelling.
Further work is required for higher tonnage band to allow CSR to be prepared
Ultimately biodegradation is epxected, but will be slow.