4,4'-methylenediphenyldiisocyanate and 2,4'-diisocyanatodiphenylmethane and their oligomerisation reaction products with 2,2'-oxydiethanol, propane-1,2-diol and butane-1,3-diol

Short-term toxicity to fish

Description of key information

A static test with zebrafish (OECD 203) indicated no mortality at 1000 mg/L after 96 hour.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

1 000 mg/L

Additional information

The test substance is covered by the category approach of methylenediphenyl diisocyanates (MDI). Hence, data of the category substances can be used to cover this endpoint. Two short-term aquatic toxicity studies are available for fish for polymeric MDI (CAS 9016-87-9). In a study with Oryzias latipes (Nakata, 1982), no acute toxicity was observed after 96h exposure to 3000 mg/L (semi-static). ). The Nichi-Nou-Sei B2735 (1965) protocol was followed, which is similar to OECD 203. A static test with Danio rerio (OECD 203) gave no mortality at 1000 mg/L, which was the highest concentration tested (Caspers, 1986). This value may be considered for the derivation of a PNEC_aqua. A third fish study with Danio rerio is available, but lacks some critical information. Hence it is classified as unreliable. The 24h-EC50 was determined to be > 500 mg/L. Based on the justification in the category approach of methylenediphenyl diisocyanates (MDI), it is assumed that all MDI analogues included in the category have a similar fish toxicity.