Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1977
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Single oral dose toxicity determined by the method of Smyth et al. (1962), no details on method provided.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Oxalic acid
EC Number:
205-634-3
EC Name:
Oxalic acid
Cas Number:
144-62-7
Molecular formula:
C2H2O4
IUPAC Name:
oxalic acid
Test material form:
solid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Doses:
Not specified
No. of animals per sex per dose:
Not specified
Control animals:
not specified
Statistics:
The LD50 and its 95% confidence limits are estimated by the moving average technique (Thompson, 1947; Weil, 1952).

Rfce:
THOMPSON, W. R. (1947). Use of moving averages and interpolation to estimate median-effective dose. I. Fundamental formulae, estimation and error, and relation to other methods: Bact.Rev. 11, 115-145.
WElL, C. S. ( 1952). Tables for convenient calculations of median-effective dose and instructions in their use. Biometrics 8, 249-263.

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
9.5 mL/kg bw
95% CL:
>= 5.4 - <= 12.3
Remarks on result:
other: 5% aqueous solution of oxalic acid
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
7.5 mL/kg bw
95% CL:
>= 5 - <= 11
Remarks on result:
other: 5% aqueous solution of oxalic acid

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
In a single oral toxicity test with a 5% aqueous solution of oxalic acid, an LD50 of 9.5 mL/kg was determined in male rats, and an LD50 of 7.5 mL/kg was determined in female rats, under the current test conditions.
Considering a density of 0.813g/mL and the dilution into 5% aqueous solution, the LD50 considered for classification are LD50 = 386.17 in male rats, & LD50 = 304.87 in female rats.
Executive summary:

In this study, the single oral dose toxicity of 110 organic and inorganic compounds, including oxalic acid, was tested. For a 5% aqueous solution of oxalic acid, an LD50 of 9.5 mL/kg was determined in male rats, and an LD50 of 7.5 mL/kg was determined in female rats, under the current test conditions.