Registration Dossier
Registration Dossier
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EC number: 203-819-3 | CAS number: 110-96-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- other: collection of data
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- SIDS INITIAL ASSESSMENT PROFILE - Aliphatic Secondary Amines
- Author:
- OECD
- Year:
- 2 013
Materials and methods
- GLP compliance:
- not specified
Test animals
- Species:
- rabbit
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- All members of the aliphatic secondary amine category are corrosive to the skin (rabbits, primarily in Draize tests or similar to OECD TG 404). No eye irritation data are available for DIBA and DPeA. Based on the available data for the remaining category members (rabbit, no guideline specified or similar to OECD TG 405) and known eye irritation potential of alkyl amines in general, it is expected that all the amines in the category are corrosive to the eye.
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