Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
The rat oral LD50 for hexadecanol and octadecanol is >2000 mg/kg. At this dose level there were no signs of toxicity (Hempstock 1996, Hempstock 1991). Administration of a single oral dose of lanolin alcohol at 2000 mg/kg bw) to rats revealed no toxic symptoms (Leushner 2001).
The oral LD50 of acetic acid in rats > 2000mg/kg bw (HSDB database)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The dermal study is waived based on the fact that the substance is not classified for acute oral toxicity or STOT3.
The information on the hydrolysis products is expected to be representative for effects of the substance. The ester will hydrolyse in the gastro-intestinal tract and systemic exposure is expected to be related to the hydrolysis products.
Justification for classification or non-classification
Based on the information available the substance does not need to be classified for acute toxicity according to EC Regulation 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
