Registration Dossier
Registration Dossier
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EC number: 915-680-2 | CAS number: -
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- no
- Remarks:
- Not applicable ( prior to 1981)
- Type of assay:
- in vitro mammalian cell transformation assay
Test material
- Reference substance name:
- Reaction mass of phosphonic acid, methyl-, bis[(5-ethyl-2-methyl-2,2-dioxido-1,3,2-dioxaphosphorinan-5-yl)methyl] ester with (5-ethyl-2-methyl-2-oxido-1,3,2-dioxaphosphorinan-5-yl)methyl methyl methylphosphonate
- EC Number:
- 915-680-2
- Cas Number:
- 170836-68-7
- Molecular formula:
- not applicable for UVCB substance
- IUPAC Name:
- Reaction mass of phosphonic acid, methyl-, bis[(5-ethyl-2-methyl-2,2-dioxido-1,3,2-dioxaphosphorinan-5-yl)methyl] ester with (5-ethyl-2-methyl-2-oxido-1,3,2-dioxaphosphorinan-5-yl)methyl methyl methylphosphonate
- Test material form:
- liquid
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1538
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Details on mammalian cell type (if applicable):
- different strains of indicator microorganisms ( S cerevisiae (strain D4), Salmonella typhimurium strains TA 1535, TA1537, TA1538, TA-98 TA-100).
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- The dose range employed was 0.01 μL to 5μL per plate.
- Vehicle / solvent:
- DMSO
Controls
- Positive controls:
- yes
- Positive control substance:
- not specified
- Details on test system and experimental conditions:
- The results of the tests conducted in the absence of a metabolic system were all negative
The results of the tests conducted in the presence of the rat liver activation system were all negative
Results and discussion
Test resultsopen allclose all
- Key result
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Key result
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Key result
- Species / strain:
- S. typhimurium TA 1538
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Key result
- Species / strain:
- S. typhimurium TA 1537
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Key result
- Species / strain:
- S. typhimurium TA 1535
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- The results of the tests conducted in the absence of a metabolic system were all negative
The results of the tests conducted in the presence of the rat liver activation system were all negative. The substance did not demonstrate mutagenic activity in any of the assays conducted in this evaluation and is considered not mutagenic under these test conditions. - Executive summary:
The results of the tests conducted in the absence of a metabolic system were all negative
The results of the tests conducted in the presence of the rat liver activation system were all negative. The substance did not demonstrate mutagenic activity in any of the assays conducted in this evaluation and is considered not mutagenic under these test conditions.
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