Reaction mass of 1,1,2,2,3,3,4,4-octafluoro-1,4-diiodobutane and 1,6-diiodoperfluorohexane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1998

Report date:

1998

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The test substance was administered neat by oral gavage to one male rat each at dosages of 450, 670, 1000, 1500, 2300 or 3400 mg/kg.

GLP compliance:

not specified

Test type:

standard acute method

Test material

Test material information

Constituent 1

Test material form:

liquid

Details on test material:

- Purity: Not reported

Test animals

Species:

rat

Strain:

not specified

Sex:

male

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

450, 670, 1000, 1500, 2300 or 3400 mg/kg

No. of animals per sex per dose:

1

Control animals:

no

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD0

Effect level:

> 3 400 mg/kg bw

Based on:

test mat.

Other findings:

At necropsy, the livers were enlarged while the testes and accessory sex organs were small. Microscopic examination revealed minimal to mild centrilobular hypertrophy and midzonal fatty change in livers and minimal to moderate degeneration/atrophy of seminiferous tubules in the testes. While the lesions in the liver were considered test substance-related, the testicular changes could be related to either the test substance, the marked body weight losses during the test period, or a combination of both.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

LD50 > 3400 mg/kg

Executive summary:

The test substance was administered neat by oral gavage to one male rat each at dosages of 450, 670, 1000, 1500, 2300 or 3400 mg/kg. Under the conditions of this test, the approximate lethal dose was greater than 3400 mg/kg. The death of the rat treated with 1500 mg/kg was attributed to animal variability since the rats treated at 2300 and 3400 mg/kg survived the study. At necropsy, the livers were enlarged while the testes and accessory sex organs were small. Microscopic examination revealed minimal to mild centrilobular hypertrophy and midzonal fatty change in livers and minimal to moderate degeneration/atrophy of seminiferous tubules in the testes. While the lesions in the liver were considered test substance-related, the testicular changes could be related to either the test substance, the marked body weight losses during the test period, or a combination of both.