Registration Dossier
Registration Dossier
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EC number: 227-842-3 | CAS number: 6000-44-8
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because a pre-natal developmental toxicity study is available
- Justification for type of information:
- Groups of 50 male and 50 female F344 DuCrj rats (aged 6 weeks) were given drinking-water containing 0, 2.5 or 5% glycine (equivalent to approximately 0, 2500 or 5000mg/kgbw per day) for 108 weeks. A complete histopathological evaluation performed at necropsy with no effects noted on any reproductive organs.
Developmental toxicity was investigated in mice, rats, and hamsters. No treatment-related effects were seen in the number of implantation sites, resorbed or dead fetuses, number of live fetuses, sex distribution,or fetal external, visceral, or skeletal deveopment.
Data source
Materials and methods
Results and discussion
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
