Registration Dossier
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EC number: 258-605-2 | CAS number: 53523-90-3
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Council Regulations EC No 440/2008, Guideline Part A
- Version / remarks:
- Methods for the Determination of the physical-chemical properties, A.6, “Water solubility”
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: OECD guideline for testing of chemicals No: 105
- Deviations:
- no
- Principles of method if other than guideline:
- The 1-octanol solubility of the test item Bayscript Gelbkomponente is determined according OECD Guideline 105 and EC Guideline A.6. The flask method was chosen for the determination of the 1-octanol solubility.
For the main test, a concentration of about 0.4 g/l of the test item for saturation is dissolved in 1-octanol. The vessels are stoppered and stirred on a magnetic stirrer for 24 h, 48 h and 72 h at 30 °C in a thermostated water bath. Following this procedure, the temperature is reduced to 20 °C and is kept in the thermostated water bath for another 24 h. After phase separation by filtration with a disposable syringe filter and/or centrifugation, respectively, the concentration of the test item in the solutions is determined. - GLP compliance:
- yes
- Specific details on test material used for the study:
- Sample number: 2835
Date of receipt: 2016-06-20
Expiry date: 2018-06-17 - Medium:
- n-octanol
- Solubility:
- 0.022 g/L
- Temp.:
- 20 °C
- Test substance stable:
- yes
- Details on results:
- Remark: Increasing 1-octanol solubilities of the test item Bayscript Gelbkomponente between 0.0114 g/l (24hours, Flask 3) and 0.0252 g/l (72 hours, Flask 1) were observed. Therefore the mean value was calculated with the concentrations of Flask 1 and Flask 2.
- Conclusions:
- The 1-octanol solubility of the test item Bayscript Gelbkomponente in 1-octanol determined by HPLC at 20 °C was 0.022 g/l.
- Executive summary:
The 1-octanol solubility of the test item Bayscript Gelbkomponente in 1-octanol determined by HPLC at 20 °C was:
Test at 20 °C Flask 1 Flask 2 Flask 3 Mean value of Flask 1 and Flask 2 1 -Octanol solubility of Bayscript Gelbkomponente 0.0252 g/l 0.0194 g/l 0.0114 g/l 0.022 g/l Result of the preliminary test: 0.0599 g/l Remark: Increasing 1-octanol solubilities of the test item Bayscript Gelbkomponente between 0.0114 g/l (24hours, Flask 3) and 0.0252 g/l (72 hours, Flask 1) were observed. Therefore the mean value was calculated with the concentrations of Flask 1 and Flask 2.
Result of the preliminary test: 0.0599 g/l.
The determination of the 1-octanol solubility was based on Council Regulations EC No 440/2008, Guideline Part A – Methods for the Determination of the physical-chemical properties, A.6, “Water solubility” and to the OECD guideline for testing of chemicals No: 105 “Water solubility“.
Reference
| Test at 20 °C | Flask 1 | Flask 2 | Flask 3 | Mean value of Flask 1 and Flask 2 |
| 1 -Octanol solubility of Bayscript Gelbkomponente | 0.0252 g/l | 0.0194 g/l | 0.0114 g/l | 0.022 g/l |
Result of the preliminary test: 0.0599 g/l.
Description of key information
The 1-octanol solubility of the test item Bayscript Gelbkomponente in 1-octanol determined by HPLC at 20 °C was:
| Test at 20 °C | Flask 1 | Flask 2 | Flask 3 | Mean value of Flask 1 and Flask 2 |
| 1 -Octanol solubility of Bayscript Gelbkomponente | 0.0252 g/l | 0.0194 g/l | 0.0114 g/l | 0.022 g/l |
| Result of the preliminary test: 0.0599 g/l | ||||
Remark: Increasing 1-octanol solubilities of the test item Bayscript Gelbkomponente between 0.0114 g/l (24hours, Flask 3) and 0.0252 g/l (72 hours, Flask 1) were observed. Therefore the mean value was calculated with the concentrations of Flask 1 and Flask 2.
Result of the preliminary test: 0.0599 g/l.
The determination of the 1-octanol solubility was based on Council Regulations EC No 440/2008, Guideline Part A – Methods for the Determination of the physical-chemical properties, A.6, “Water solubility” and to the OECD guideline for testing of chemicals No: 105 “Water solubility“.
Key value for chemical safety assessment
- At the temperature of:
- 20 °C
- Solubility in organic solvents at 20°C:
- 0.022 g/L
Additional information
Solubility in 1-octanol
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