Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 812-963-1 | CAS number: 178436-06-1
Toxicity to aquatic plants other than algae
Administrative data
- Endpoint:
- toxicity to aquatic plants other than algae
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Valid QSAR model applied (Epi-Suite v 4.1)
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Epi-Suite QSAR calculation
- Version / remarks:
- 4.1
- Principles of method if other than guideline:
- QSAR calculation (EPI-Suite EPIWIN v 1.4)
Smiles notation applied: CCCCCCCCC=CCCCCCCCC(=O)NC(CO)C(C(CCCCCCCCCCCCCC)O)O
Test material
- Reference substance name:
- Ceramides
- EC Number:
- 309-560-3
- EC Name:
- Ceramides
- Cas Number:
- 100403-19-8
- Molecular formula:
- C36 H71 N1 O4
- IUPAC Name:
- Ceramides
1
Test organisms
- Test organisms (species):
- other: Green algae
Results and discussion
Effect concentrations
- Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0 mg/L
- Nominal / measured:
- estimated
- Basis for effect:
- not specified
- Details on results:
- Applying the water solubility SW =1.8E-008 mg/L and the octanol-water partitioning coefficient Log Kow = 11.79 (KOWWIN version 1.68 estimate)) the estimated toxicity towards daphnids was calculated.
The calculated toxicity towards algae was above the calcualted water solubility of the test substance.
96-hr, LC50 = 0.000105 mg/L - Results with reference substance (positive control):
- Not applicable
Applicant's summary and conclusion
- Conclusions:
- The calculated toxicity was above the calcualted water solubility of the test substance.
96-hr, LC50 = 0.000105 mg/L - Executive summary:
A QSAR calculation was performed applying EPI-Suite (EPIWIN v. 1.4), smiles notation : CCCCCCCCC=CCCCCCCCC(=O)NC(CO)C(C(CCCCCCCCCCCCCC)O)O and the following input parameters:
SW =1.8E-008 mg/L; Log Kow = 9.33 (KOWWIN version 1.68 estimate)
The calculated toxicity towards algae was above the calcualted water solubility of the test substance.
96-hr, LC50 = 0.000105 mg/L
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
