Registration Dossier
Registration Dossier
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EC number: 202-856-2 | CAS number: 100-48-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7 Aug 1978 to 23 Aug 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Isonicotinonitrile
- EC Number:
- 202-856-2
- EC Name:
- Isonicotinonitrile
- Cas Number:
- 100-48-1
- Molecular formula:
- C6H4N2
- IUPAC Name:
- pyridine-4-carbonitrile
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- five groups of five male albino rats of Sherman-Wistar strain weighing between 200 and 300 grams. Deprived of food but not water for 24 hours prior to dosing.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Each animal weighed and dosed by direct administration of experimental material into the stomach by means of a syringe and dosing needle. Following administration, the animals were allowed food and water ad libitum for 14 day observation period, during which time rats were observed for signs of toxicity and mortality.
- Doses:
- 250, 500, 1000, 2000, 4000 mg/kg
- No. of animals per sex per dose:
- 5 males per dose
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 710 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 500 - <= 1 000
- Mortality:
- 0/5 in 250 and 500 mg/kg groups.
1000 mg/kg group: deaths at day 3 (2), day 6 (2) and day 8 (1)
2000 mg/kg group: deaths at day 1 (4) and day 2 (1)
4000 mg/kg group: 5/5 dead at day 1 - Clinical signs:
- other: At 250 mg/kg, animals appeared slightly depressed after 2 hours but appeared normal after 24 hours. At 500 mg/kg, animals were lethargic after 1 hour and remained depressed for up to 48 hours. At 1000 mg/kg, animals were depressed after 30 minutes and e
- Gross pathology:
- Gross pathologic examination revealed nothing remarkable.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Acute oral LD50 (rat) for 4-Cyanopyridine is 710 mg/kg.
- Executive summary:
Acute oral LD50 (rat) for 4-Cyanopyridine is 710 mg/kg.
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