Carvacrol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from publication.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Report on the Safety Assessment of the given test chemical.

Author:

COSMETIC INGREDIENT REVIEW

Year:

2006

Bibliographic source:

International Journal of Toxicology

Reference 2

Reference Type:

publication

Title:

Monograph - Test chemical

Author:

Opdyke et al.

Year:

1979

Bibliographic source:

Food and Cosmetics Toxicology

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

Acute dermal toxicity of the given test chemical in rabbit.

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Carvacrol

EC Number:

207-889-6

EC Name:

Carvacrol

Cas Number:

499-75-2

Molecular formula:

C10H14O

IUPAC Name:

2-methyl-5-(propan-2-yl)phenol

Details on test material:

- IUPAC Name: 2-methyl-5(propan-2-yl)phenol
- Common Name: Carvacrol
- InChI: 1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H3
- Smiles: CC(C)c1ccc(C)c(O)c1
- Molecular formula :C10H14O
- Molecular weight:150.2196 g/mol
- Substance type:Organic
- Physical state:Colorless to pale-yellow liquid; spicy thymol odor
- Purity: 98%
- Impurities (identity and concentrations):2%

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

not specified

Administration / exposure

Type of coverage:

other: Dermal

Vehicle:

not specified

Details on dermal exposure:

not specified

Duration of exposure:

not specified

Doses:

2500 and 5000 mg/kg bw

No. of animals per sex per dose:

Total = 10

Control animals:

not specified

Details on study design:

- Other examinations performed: Animals were observed for mortality and clinical signs.
- Necropsy of survivors performed: yes

Statistics:

not specified

Results and discussion

Preliminary study:

not specified

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

1/8 rabbits died in the 5000 mg/kg group.

Clinical signs:

other: The rabbit that died in the 5000 mg/kg group had a bluish tinge to eyes, nose, and ears and slight lethargy was also noted. Panting was observed in one other rabbit.

Gross pathology:

Necropsy findings were routine.

Other findings:

not specified

Applicant's summary and conclusion

Interpretation of results:

other: Not classified

Conclusions:

The acute dermal LD50 value was considered to be >5000 mg/kg bw, when 10 rabbits were treated with the given test chemical by dermal application.

Executive summary:

Acute dermal toxicity study of the given test chemical was conducted in 10 rabbits at the dose concentration of 2500 and 5000 mg/kg bw. The given test chemical was applied to the skin of rabbits. Animals were observed for mortality and clinical signs. Necropsy of survivors was performed. 1/8 rabbits died in the 5000 mg/kg group. The rabbit that died in the 5000 mg/kg group had a bluish tinge to eyes, nose, and ears and slight lethargy was also noted. Panting was observed in one other rabbit. Necropsy findings were routine. Hence, LD50 value was considered to be >5000 mg/kg bw, when 10 rabbits were treated with the given test chemical by dermal application.