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EC number: 291-350-5 | CAS number: 90387-74-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Glycine, N-coco acyl derivs., sodium salts
- EC Number:
- 291-350-5
- EC Name:
- Glycine, N-coco acyl derivs., sodium salts
- Cas Number:
- 90387-74-9
- Molecular formula:
- Molecular formula for this UVCB is not available.
- IUPAC Name:
- Glycine, N-coco acyl derivs., sodium salts
Constituent 1
- Specific details on test material used for the study:
- Name: Sodium Cocoyl Glycinate (GCS-12)
Lot No.: 970925
Description: Clear liquid
Composition: 31.5% solution
Storage condition: Cool, dark place
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- not further specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- yes, concurrent vehicle
- yes, concurrent positive control
- Amount / concentration applied:
- TEST MATERIAL
0.3 mL of a 5% (w/w) solution
VEHICLE
0.3 mL of distilled water for injection
POSITIVE CONTROL
0.3 mL of a 5% (w/w) SLS solution - Duration of treatment / exposure:
- 24 h
- Observation period:
- up to 1 week
- Number of animals:
- 6 per group
- Details on study design:
- On the day before application, the hair on flank of the rabbits was shorn using electric hair clippers. Six healthy rabbits that did not have uneven hair growth were selected for the study.
On the day of application, 0.3 mL of distilled water for injection, 5% (w/w) test item or 5% (w/w) SLS solution was applied to the cotton area of a patch (2.5 cm in diameter) using a disposable syringe. The patch was then applied to the shorn area. Following application, the rabbits were fitted with a vest for 24 hours (closed patch testing). The vest and the patch were removed 24 hours following application. Thirty minutes later, the levels of erythema and edema at the test site were evaluated using the Draize scale.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 1.4
- Reversibility:
- fully reversible within: 7 d
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on a primary dermal irritation index (PDII) of 1.4 it can be concluded that the test item (5% w/w solution) will not be irritant to the skin of rabbits.
- Executive summary:
A primary dermal irritation study with the test item was conducted in rabbits using the Draize method (24 -hour occlusive patch). Based on a primary dermal irritation index (PDII) of 1.4, a significant skin irritation potential of the test item (5% w/w solution) is not to be expected.
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