Registration Dossier
Registration Dossier
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EC number: 279-349-8 | CAS number: 79916-07-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- A review of toxicity of twelve fluorescent dyes used for water tracing
- Author:
- P.L Smart
- Year:
- 1 984
- Bibliographic source:
- The NSS Bulletin 21-33, 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Acute oral toxicity of rhodamine B in rats
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- 9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthylium chloride
- EC Number:
- 201-383-9
- EC Name:
- 9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthylium chloride
- Cas Number:
- 81-88-9
- Molecular formula:
- C28H31N2O3.Cl
- IUPAC Name:
- 9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthenium chloride
- Reference substance name:
- Rhodamine B
- IUPAC Name:
- Rhodamine B
- Test material form:
- other: Solid
- Details on test material:
- - Name of test material (as cited in study report): Rhodamine B
- Molecular formula: C28-H31-N2-O3.Cl
- Molecular weight: 479.017 g/mole
- Substance type: Organic
- Physical state: Solid
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Rhodamine B
- Molecular formula (if other than submission substance): C28-H31-N2-O3.Cl
- Molecular weight (if other than submission substance): 479.017 g/mole
- Substance type: Organic
- Physical state: Solid
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data
- Doses:
- 500 mg/kg
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality
- Mortality:
- No mortality was noted at the tested concentration in rats.
- Clinical signs:
- No data
- Body weight:
- No data
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD50 was considered to be > 500 mg/kg when rats were treated with rhodamine B orally.
- Executive summary:
In a acute oral toxicity, rats were treated with rhodamine B in the concentration of 500 mg/kg orally. No mortality observed in treated rats. Therefore, LD50 was considered to be > 500 mg/kg when rats were treated with rhodamine B orally.
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