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EC number: 214-686-6 | CAS number: 1185-57-5
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Experimental test result performed using standard test guidelines
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 101
- GLP compliance:
- no
- Type of method:
- other: spectrophotometric analytical method
- Key result
- Water solubility:
- 580.8 g/L
- Conc. based on:
- test mat.
- Temp.:
- 25 °C
- Remarks on result:
- other: No other detail available
- Conclusions:
- The study was conducted to determine the solubility of test chemical in ultra-pure water, according to the OECD guideline 105 and OECD 101. Test was conducted at 25±2 °C in two stages; preliminary test for 24/96 h, followed by confirmatory test for 24 h, 48 h and 72 h in replicates. The final water solubility value was calculated based on average of the individual values obtained after 24 h, 48 h and 72 h. The difference between the average values in three vessels was not observed more than 15%. The water solubility value was observed to be 580.8 g/L at 25°C.
- Executive summary:
The study was conducted to determine the solubility of test chemical in ultra-pure water, according to the OECD guideline 105 and OECD 101. Test was conducted at 25±2 °C in two stages; preliminary test for 24/96 h, followed by confirmatory test for 24 h, 48 h and 72 h in replicates. The final water solubility value was calculated based on average of the individual values obtained after 24 h, 48 h and 72 h. The difference between the average values in three vessels was not observed more than 15%. The water solubility value was observed to be 580.8 g/L at 25°C.
Reference
Obseravtionn Table:
Sample stirring (hours) |
Concentration obtained |
Average |
Absorbance |
Average |
Dilution Factor |
Water solubility value obtained (mg/l) |
Average |
24 hrs. |
R1 |
11.637 |
11.661 |
0.564 |
0.565 |
50000 |
583050 |
24 hrs. |
R2 |
11.685 |
|
0.567 |
|
|
|
48 hrs. |
R1 |
11.082 |
11.08 |
0.537 |
0.537 |
50000 |
554425 |
48 hrs. |
R2 |
11.095 |
|
0.538 |
|
|
|
72 hrs. |
R1 |
12.090 |
12.096 |
0.586 |
0.586 |
50000 |
604925 |
72 hrs. |
R2 |
12.107 |
|
0.587 |
|
|
|
Description of key information
The study was conducted to determine the solubility of test chemical in ultra-pure water, according to the OECD guideline 105 and OECD 101. Test was conducted at 25±2 °C in two stages; preliminary test for 24/96 h, followed by confirmatory test for 24 h, 48 h and 72 h in replicates. The final water solubility value was calculated based on average of the individual values obtained after 24 h, 48 h and 72 h. The difference between the average values in three vessels was not observed more than 15%. The water solubility value was observed to be 580.8 g/L at 25°C.
Key value for chemical safety assessment
- Water solubility:
- 580.8 g/L
- at the temperature of:
- 25 °C
Additional information
Various experimental studies from different databases have been used to determine the water solubility of test chemical. The studies are as mentioned below:
The study was conducted to determine the solubility of test chemical in ultra-pure water, according to the OECD guideline 105 and OECD 101. Test was conducted at 25±2 °C in two stages; preliminary test for 24/96 h, followed by confirmatory test for 24 h, 48 h and 72 h in replicates. The final water solubility value was calculated based on average of the individual values obtained after 24 h, 48 h and 72 h. The difference between the average values in three vessels was not observed more than 15%. The water solubility value was observed to be 580.8 g/L at 25°C.
Water solubility of test chemical was determined to be 1200000 mg/L at 20 °C. According to the determined water solubility of test chemical, it can be consider that the test chemical was highly soluble in water.
Similar studies from handbooks and authoritative databases were used. Under the test condition it was observed that the test chemical was highly soluble in water.
Thus based on the overall studies, it was concluded that the test chemical was highly soluble in water.
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