Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 454-790-0 | CAS number: -
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21.06.2004-07.07.2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.1110 (Activated Sludge Sorption Isotherm)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- other: reversed phase column packed with a commercial\y available cyanopropyl solid phase containing lipophilic and polar moieties
- Radiolabelling:
- no
- Details on study design: HPLC method:
- Reagents
Acetonitrile, Chromasolv Riedel de Haen
Methanol, Chromasolv Riedel de Haen
Cleaned water (laboratory equipment)
Distilled water, Roth
Dead time marker: Formamide, Merck
Calibration substances (Merck, Riedel de Haen, Table 2 and 4)
Instruments
Chromatographie apparatus refer chapter 4.4
Analytical balance Sartorius Rrn·o P
Ultrasonic bath Branson 3200
Variable pipettes, Brand
General laboratory glassware
HPLC equipment: HPLC pump G1312A, autosampler G1313A, column oven G1316A, degaser G1322A and Diode Array Detector G1315B by Agilent
Column: stationary phase: LiChrospher 100 CN 5μm by Duratec (9911-02)
material: stainless steel, dimensions: 250 mm x 4.6 mm
column temperature: 25 °C
Mobile Phase: methanol / cleaned water 75:25 % (v/v), isocratic elution
Flow rate: 1.0 ml/min
lnjection volume: 10 μI
Detection wavelength: 210 nm (dead time marker and calibration substances)
230 nm (lest item)
Injection amounts:
Dead time marker: 17.4 μg
Calibration substances: 0.68-1.93 μg
Testitem: 0.49 μg
The dead time marker and the calibration substances were dissolved in acetonitrile and diluted 0.1 to 1 in eluent and injected as single standards twice. The item was dissolved in methanol and diluted 0.1 to 1 in eluent and injected as single solution twice. - Key result
- Sample No.:
- #1
- Type:
- log Koc
- Value:
- ca. 3.448 dimensionless
- pH:
- 7
- Temp.:
- 25 °C
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient of the test item was found to be: log Koc 3.4
- Executive summary:
The adsorption coefficient of the test item was determined according to the "HPLC-method" described in guideline 67/548/EEC, annex C.19.
The adsorption coefficient of the test item was found to be: log Koc 3.4
Reference
Description of key information
The adsorption coefficient of the test item was found to be: log Koc 3.4
Key value for chemical safety assessment
- Koc at 20 °C:
- 2 511.89
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
