Registration Dossier
Registration Dossier
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EC number: 947-119-2 | CAS number: -
Endpoint summary
Administrative data
Description of key information
The acute toxicity data presented here are based on close structural analogues, primarily DNNSA.
In acute oral testing, the LD50 was greater than 5000 mg/kg (2500 mg/kg
based on purity). One of 10 animals died at a dose of 5000 mg/kg.
In acute dermal testing, the LD50 was greater than 2 milliliters/kg or
2000 mg/kg (1000 mg/kg based on purity). No adverse effects were
observed.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 500 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating conc.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 1 000 mg/kg bw
Additional information
The available testing showed that DNNSA has low toxicity by oral and dermal routes. Based on the results of the acute oral test (LD50 > 2500 mg/kg) it is reasonable to assume that a dose of 2000 mg/kg in the dermal study would also have shown no mortality.
Justification for selection of acute toxicity – oral endpoint
Scientifically sound study following acceptable testing procedure.
Justification for selection of acute toxicity – inhalation endpoint
The use as a lubricant additive is unlikely to result in significant
human exposure to inhalable droplets.
An inhalation study is available that was conducted with a 1 hour
exposure (4 hour exposure is required). This study showed no toxicity at
an exposure of 200 mg/Liter (Acute Inhalation Study, Report T-307,
February 27, 1978 with Synex 1052 (50% DNNSA).
Justification for selection of acute toxicity – dermal endpoint
Scientifically sound study following acceptable testing procedure.
Justification for classification or non-classification
Based on finding in acute oral, dermal and inhalative studies with the substance it can be concluded that no classification for acute toxicity by oral, dermal or inhalative route is required according to CLP (Regulation EC No 1272/2008) or DSD (Directive 67/548/EEC). Given the high viscosity and the fact that DNNSA is not a pure hydrocarbon, classification for aspiration hazards is not required. No specific target organ toxicity was observed in any of the acute studies and thus STOT single exposure classification is not required.
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