Registration Dossier
Registration Dossier
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EC number: 207-313-3 | CAS number: 461-72-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Version / remarks:
- No reference to a guideline provided in the publication.
- Principles of method if other than guideline:
- Non-pregnant female CD-1 mice were intraperitonally injected hydantoin suspended in methylcellulose on 3 consecutive days. Mortality was recorded for up to 14 days following the final injection.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Hydantoin
- EC Number:
- 207-313-3
- EC Name:
- Hydantoin
- Cas Number:
- 461-72-3
- Molecular formula:
- C3H4N2O2
- IUPAC Name:
- hydantoin
- Test material form:
- not specified
Constituent 1
- Specific details on test material used for the study:
- Material was greater than 98% pure, as determined by GLC, TLC, and NMR techniques.
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Adult female non-pregnant CD-1 mice (Charles River Laboratories, Wilmington, Mass.)
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- methylcellulose
- Remarks:
- suspension, 0.5%, w/w, 1 mL/100 g body wt
- Details on exposure:
- Single daily ip injections on 3 consecutive days
- Doses:
- Not specified
- No. of animals per sex per dose:
- Not specified
- Control animals:
- not specified
- Details on study design:
- Mortality was recorded for up to 14 days following the final injection.
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 53.7 other: mmol/kg/day
- Based on:
- test mat.
- 95% CL:
- 47.6 - 62.1
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 5 374 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 4 764 - <= 6 215
- Remarks on result:
- other: calculated based on the mmol/kg/day values
- Mortality:
- Yes, but no details stated
- Clinical signs:
- Not specified
- Body weight:
- Not specified
- Gross pathology:
- Not specified
Applicant's summary and conclusion
- Conclusions:
- Female non-pregnant CD-1 mice were administered hydantoin intraperitoneally daily on 3 consecutive days. The resulting LD50 was calculated to be 5374 mg/kg bw/day (4764 - 6215 mg/kg bw/day).
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