Registration Dossier
Registration Dossier
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EC number: 215-709-2 | CAS number: 1344-81-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: EPA FIFRA guidelines Pesticide Assessment Guidelines Subsection F
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Calcium sulfide (Ca(Sx))
- EC Number:
- 215-709-2
- EC Name:
- Calcium sulfide (Ca(Sx))
- Cas Number:
- 1344-81-6
- Molecular formula:
- CaSx (X=2,3,4,5,6,7)
- IUPAC Name:
- Calcium sulfide (Ca(Sx)
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Elkhorn Rabbitry, Watsonville, CA
5 males and 5 females weighting at least 2 kg each
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- See it in the attachement page 5. procedure 3.4.5. paragraph.
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 female and 5 male rabbits
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals survived the test period.
- Clinical signs:
- other: Several local irritation including necrosis was observed on all of the animals on the skin of the test sites. Wounds were beaginnig to heal by day 10. No systemic toxic signs were observed during the test.
- Gross pathology:
- No test compound related abnormalities were observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- At a dermal dose of 2000 mg/kg bw, this test compund produces no mortalities among male and female NZW rabbits.
- Executive summary:
At a dermal dose of 2000 mg/kg bw, this test compund produces no mortalities among male and female NZW rabbits.
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