Registration Dossier
Registration Dossier
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EC number: 209-042-6 | CAS number: 553-54-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The effects of benzoic acid, sodium benzoate and lithium salts have been considered in this review.
The toxicity to sodium benzoate (IC50 30 mg/l) appears significantly greater than the toxicity of benzoic acid, suggesting that the sodium itself may be leading to reduction in growth rate. This study obtained from the ECHA web-site (disseminated dossiers) has been provided as part of the overal weight of evidence in determining if the lithium salt of benzoic acid is hazardous to aquatic organisms.
The toxicity of lithium was estimated from different sources, with the lowest reliable IC50 of approximately 12 mg/l Li
It is considered conservative to use the IC50 of 30 mg/l to set a figure for estimating PNEC.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 30 mg/L
Additional information
Based on the lowest reported lithium IC50 of 12 mg/l, it is estimated that the IC50 (growth) for lithium benzoate would be ca 200 mg/l if the lithium was the determining factor. However, the results for sodium benzoate suggest a higher level of effect and it is proposed to use the same IC50 for lithium benzoate as is used for sodium benzoate.
Publications suggest lower toxicity for both benzoate salts and lithium, but the more conservative figures based on sodium benzoate are cited.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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