4-methylbenzophenone

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1998

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data from peer-reviewed data base. Tests were performed under the authority of the Ministry of Environment of Japan according OECD Guidelines and GLP and are therefore regarded as peer-reviewed and reliable with restriction.

Data source

Reference

Reference Type:

other: peer-reviewed database

Title:

Unnamed

Year:

2010

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 201 (Alga, Growth Inhibition Test)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Benzophenone

EC Number:

204-337-6

EC Name:

Benzophenone

Cas Number:

119-61-9

Molecular formula:

C13H10O

IUPAC Name:

benzophenone

Details on test material:

- Name of test material (as cited in study report): benzophenone
- Substance type: aromatic ketone
- Physical state: solid (25°C; melting point: ca. 48°C)
- Analytical purity: not reported
- Impurities (identity and concentrations): not reported
- Stability under test conditions: not reported
- Storage condition of test material: not reported

Sampling and analysis

Analytical monitoring:

not specified

Test solutions

Vehicle:

not specified

Test organisms

Test organisms (species):

Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)

Study design

Test type:

static

Water media type:

freshwater

Total exposure duration:

72 h

Test conditions

Reference substance (positive control):

not specified

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

3.5 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

growth rate

Effect concentrations 2

Duration:

72 h

Dose descriptor:

NOEC

Effect conc.:

1 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

growth rate

Applicant's summary and conclusion

Conclusions:

In a 72 hour acute toxicity study, the cultures of Pseudokirchnerella subcapitata were exposed to benzophenone in accordance with the OECD Guideline 201 (Alga, Growth Inhibition Test).  The EC50 value based on growth rate was 3.5 mg test mat./L.  The NOEC values based on growth rate was 1.0 mg test mat./L.Based on the similar structure and physico-chemical properties a very similar fate and behavior of 4 -methylbenzophenone can be assumed. Therefore it can be concluded that the toxicity of 4 -methylbenzophenone will be very similar to that of benzophenone. Therefore, and furthermore with respect to animal welfare, the performance of any new experimental tests on 4-methylbenzophenone is assumed to be not justifiable. Instead, results from reliable key studies performed with benzophenone can be regarded as a sound basis for assessing the environmental effects of 4-methylbenzophenone.
 
 

Executive summary:

In a 72 hour acute toxicity study, the cultures of Pseudokirchnerella subcapitata were exposed to benzophenone in accordance with the OECD Guideline 201 (Alga, Growth Inhibition Test).  The EC₅₀values based on growth rate was 3.5 mg test mat./L.  The NOEC values based on growth rate was 1.0 mg test mat./L.

 

This toxicity study is classified as reliable with restrictions and satisfies the guideline requirements for an algae growth inhibition study.

 

Results Synopsis

 

Test Organism:Pseudokircheneriella subcapitata

Test Type: OECD Guideline 201 (Alga, Growth Inhibition Test), static

 

72-hr ErC₅₀: 3.5 mg test mat./L

72-hr NOEC (growth rate): 1.0 mg test mat./L

Based on the similar structure and physico-chemical properties a very similar fate and behavior of 4 -methylbenzophenone can be assumed. Therefore it can be concluded that the toxicity of 4 -methylbenzophenone will be very similar to that of benzophenone. Therefore, and furthermore with respect to animal welfare, the performance of any new experimental tests on 4-methylbenzophenone is assumed to be not justifiable. Instead, results from reliable key studies performed with benzophenone can be regarded as a sound basis for assessing the environmental effects of 4-methylbenzophenone.