Registration Dossier
Registration Dossier
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EC number: 286-283-3 | CAS number: 85203-92-5
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility (OECD 201); read-across
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity of Octadecanoic acid, C16-20-branched alkyl esters (CAS 85203-92-5) to aquatic algae are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substances 2-octyldodecyl isooctadecanoate (CAS 93803-87-3) and Lauryl Oleate (CAS 36078-10-1) was conducted. The source substance 2-octyldodecyl isooctanoate (CAS 93803-87-3) is an ester of isooctanoate (C18 iso) and 2-octyldodecanol (C20 branched). Lauryl Oleate (CAS 36078-10-1) is specified as an ester of C18 unsaturated fatty acid and C12 fatty alcohol. This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.
The study with the source substance 2-octyldodecyl isooctadecanoate was conducted according to OECD 201 (GLP) with the freshwater algae Selenastrum capricornutum Water Accommodated Fractions (WAF) of nominal 10 and 100 mg/L were prepared and tested under static conditions. A chemical analysis of the test substance concentrations in the test vessels was not possible since no applicable method could be established due to the very low water solubility to detect test concentrations. An inhibition of growth (31.2%) was observed after 72 h in the WAF test solution of 100 mg/L, whereas no inhibition was observed in the WAF test solution of 10 mg/L. It was reported that this effect is probably related to insoluble particles which might have adsorbed fractions of light needed for algal cell growth. Since both test substance concentrations are above water solubility it can be concluded that the EC50 and the NOEC exceed the maximum water solubility of the test substance. An EL50 (72 h) of > 100 mg/L and a NOELR (72 h) of ≥ 100 mg/L were derived, respectively.
The study with the source substance lauryl oleate (CAS 36078-10-1) was performed according to OECD 201 (GLP) with the green algae Desmodesmus subspicatus. Five loading rates up to 100 mg/L (nominal) were tested in this study. The loading rates were prepared by siphoning an appropriate amount from the middle after a suitable stirring and settling period (Water Accommodated Fraction). Measured values resulted in concentrations below the Limit of Quantification (< 0.005 mg/L) for all test concentrations. No effects on the growth rate and yield resulted after an exposure of 72 h. Thus a NOErLR (72 h) of ≥ 100 mg/L and an ErL50 (72 h) > 100 mg/L resulted.
Based on the available result from structurally similar source substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that Octadecanoic acid, C16-20-branched alkyl esters (CAS 85203-92-5) will not exhibit effects to aquatic algae up to the limit of water solubility.
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