Fluorobenzene

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, well documented and acceptable for assessment.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Centrolobular hepatic necrosis related to covalent binding of metabolites of halogenated aromatic hydrocarbons

Author:

Reid, W.D., Krishna, G.

Year:

1973

Bibliographic source:

Exp. Mol. Pathol., 18, 80-99

Reference 2

Reference Type:

publication

Title:

Biochemical mechanism of hepatic necrosis induced by aromatic hydrocarbons

Author:

Reid, W.D., et al.

Year:

1973

Bibliographic source:

Pharmacology, 10, 193-214

Reference 3

Reference Type:

publication

Title:

Toxicological Evaluations Vol. 13

Author:

BG Chemie

Year:

1998

Bibliographic source:

Springer-Verlag Berlin Heidelberg, ISBN 3-540-62658-1

Materials and methods

Principles of method if other than guideline:

The hepatotoxic effects of fluorobcnzene and a number of other halogenated benzenes (bromobenzene, iodobenzene, o-dichlorobenzene, p-dichlorobenzene) and the relationship between hepatotoxicity, covalent binding and metabolism were studied in rats after a single intraperitoneal injection.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Fluorobenzene

EC Number:

207-321-7

EC Name:

Fluorobenzene

Cas Number:

462-06-6

Molecular formula:

C6H5F

IUPAC Name:

fluorobenzene

Details on test material:

- Locations of the label: 14C-fluorobenzene

Radiolabelling:

yes

Test animals

Species:

rat

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 160-200 g

Administration / exposure

Route of administration:

intraperitoneal

Duration and frequency of treatment / exposure:

once

Doses / concentrations

Dose / conc.:

1 other: mmol/kg bw

Remarks:

1 mmol 14C-fluorobenzene/kg body weight (equivalent to 96.11 mg/kg body weight)

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on distribution in tissues:

The concentration in the liver (1.3 nmol/g) was low in comparison with other halogenated benzenes. Only a relatively small amount of radioactivity was found in the urine (28% of the administered amount) within 24 hours of an intraperitoneal injection of the same dose.

Any other information on results incl. tables

Hepatic concentration and metabolite excretion of Fluorobenzene-¹⁴C

Substance	Time of killing (h)	Hepatic concentration^a (nmol/g ± SE)	Metabolites excreted^b (% of dose)
Fluorobenzene-^14C (1 mmol/kg)	6	1.3 ± 0.3	11
	24	0.09 ± 0.04	28

^aMean of six determinations of individual rats.

^bMean of two pools of three rats.