Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-089-1 | CAS number: 133-08-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
There is no data available for diethyl butylmalonate (CAS # 133 -08 -4). For C&L purposes, the following data available for structurally similar substances cited in the 2006 OECD SIDS “malonic acid diesters” (UNEP Publications, Final 10/2006) is suitable for read across:
Dimethylmalonate, CAS # 108-59-8
not mutagenic
Diethylmalonate, CAS # 105-53-3
not mutagenic
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There is no data available for diethyl butylmalonate (CAS # 133 -08 -4). For C&L purposes, the following data available for structurally similar substances cited in the 2006 OECD SIDS “malonic acid diesters” (UNEP Publications, Final 10/2006) is suitable for read across:
Dimethylmalonate, CAS # 108-59-8 and Diethylmalonate, CAS # 105 -53 -3:
Both materials, DMM and DEM were not mutagenic in standard Ames assays with and without
metabolic activation according to Dir. 84/449/ECC B 14 and GLP in S. typhimurium strains TA
1535, TA 1537, TA 1538, TA 98 and TA 100 up to concentrations of 5000 ug/plate. Cytotoxicity
was observed for DMM at concentrations at and above 1000 ug/plate while for DEM no cytotoxicity
was observed at the highest concentration of 5000 ug/plate (OECD SIDS, 2006).
DMM was not mutagenic in an in vitro cytogenetic assay in human peripheral lymphocytes with
and without metabolic activation according to OECD TG 473 and GLP at concentrations of up to
5000 ug/ml. A reduction in mitotic index indicating cytotoxicity was observed at a concentration of
5000 ug/ml with and without metabolic activation (OECD SIDS, 2006).
Justification for classification or non-classification
Based on the available data for read across substances Dimethylmalonate, CAS # 108-59-8 and Diethylmalonate, CAS # 105 -53 -3, there is no indication that Diethyl butylmalonate (CAS # 133 -08 -4) would require classification for genetic toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
