Registration Dossier
Registration Dossier
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EC number: 204-841-6 | CAS number: 127-41-3
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from HSDB and PubChem authoritative database
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Environmental bioconcentration factor of the test chemical in fish was estimated using a logKow and a regression-derived equation.
- GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: Fish
- Route of exposure:
- aqueous
- Test type:
- not specified
- Water / sediment media type:
- natural water: freshwater
- Reference substance (positive control):
- not specified
- Details on estimation of bioconcentration:
- BASIS FOR CALCULATION OF BCF
- Result based on calculated logKow of: 3.85 - Type:
- BCF
- Value:
- 161 dimensionless
- Basis:
- whole body w.w.
- Calculation basis:
- other: BCF value of test chemical was estimated using a logKow and a regression-derived equation.
- Remarks on result:
- other: Other details not known
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The estimated BCF (bioaccumulation factor) of test chemical was determined to be 161 dimensionless.
- Executive summary:
The bioaccumulation study in fish was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a logKow of 3.85 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 161 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-accumulative in aquatic organisms.
Reference
Description of key information
The bioaccumulation study in fish was conducted for estimating the BCF (bioaccumulation factor) value of test chemical (authoritative database, 2017). The bioaccumulation factor (BCF) value was calculated using a logKow of 3.85 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 161 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-accumulative in aquatic organisms.
Key value for chemical safety assessment
- BCF (aquatic species):
- 161 dimensionless
Additional information
Various experimental key and supporting studies of the test chemical were reviewed for the bioaccumulation end point which are summarized as below:
In an experimental key study from authoritative database (2017), bioaccumulation experiment in fish was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a logKow of 3.85 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 161 dimensionless.
Another bioaccumulation study in fish was conducted for estimating the BCF (bioaccumulation factor) value of test chemical (from handbook, 2008). The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 501 dimensionless.
For the test chemical, the bioaccumulation study in fish was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a measured logKow of 4.0 and an equation (logBCF (fish) = 0.85*logKow – 0.70). The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 501 dimensionless.
On the basis of above results for test chemical(from authoritative database and handbook, 2017), it can be concluded that the BCF value of test substancewas evaluated to be upto 501,which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.
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